{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:11Z","timestamp":1786977071841,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009972","name":"Aksaray \u00dcniversitesi","doi-asserted-by":"publisher","award":["2022\u2010013"],"award-info":[{"award-number":["2022\u2010013"]}],"id":[{"id":"10.13039\/501100009972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023316","name":"Kapadokya \u00dcniversitesi","doi-asserted-by":"publisher","award":["K\u00dcN.2023\u2010BAGP\u2010001"],"award-info":[{"award-number":["K\u00dcN.2023\u2010BAGP\u2010001"]}],"id":[{"id":"10.13039\/501100023316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Guided bone regeneration (GBR) is a regenerative surgical procedure in dentistry and orthopedics. The aim of this study is to fabricate a novel nano\u2010textured, hydrophilic thermoplastic polyurethane (TPU)\u2010based barrier membrane containing unsaturated fatty acid, oleic acid (OLE) to assist GBR. First, TPU copolymer containing OLE in different ratios was synthesized, and GBR membranes were fabricated by the solvent casting method, and then, the surface properties were improved by alkali treatment. Thus, a TPU\u2010OLE structure was obtained with improved surface wettability, the ability to prevent bacterial adhesion, and the capability to promote cell adhesion. The contact angle reduced from 73.3\u00b0\u2009\u00b1\u20091\u00b0 to 30.7\u00b0\u2009\u00b1\u20090.3\u00b0 at TPU\u2010OLE3, while at TPU it decreased from 121.2\u00b0\u2009\u00b1\u20092.5\u00b0 to 63.6\u00b0\u2009\u00b1\u20090.8\u00b0 after treatment with 3\u2009M sodium hydroxide (NaOH) solution. Furthermore, plate counting assays showed that TPU\u2010OLE membranes displayed excellent bacterial inhibition (against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ); the control group showed 6\u2009\u00d7\u200910\n                    <jats:sup>7<\/jats:sup>\n                    \u2009CFU\/mL of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    bacterial colonies, while on the plates interacting with TPU\u2010OLE1, TPU\u2010OLE2, and TPU\u2010OLE3 membranes, colonies of 12\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    , 12\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    , and 24\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    \u2009CFU\/mL were observed, respectively. The bacterial count on TPU\u2010OLE1, TPU\u2010OLE2, and TPU\u2010OLE3 membranes decreased by 109, 164, and 12\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    \u2009CFU\/mL at 24\u2009h, while the control group and TPU membranes showed 1300\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    and 600\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    \u2009CFU\/mL, respectively. The obtained results indicated that either alkali treatment or OLE\u2010modified TPU produced a more hydrophilic and promotive surface for cell attachment. Therefore, we anticipate that alkali\u2010treated TPU\u2010OLE membranes have a great potential in GBR in future applications.\n                  <\/jats:p>","DOI":"10.1002\/bip.70010","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T08:00:14Z","timestamp":1742284814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Thermoplastic Polyurethane\u2010Oleic Acid (\n                    <scp>TPU<\/scp>\n                    \u2010\n                    <scp>OLE<\/scp>\n                    ) Membranes for Guided Bone Regeneration"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-9792","authenticated-orcid":false,"given":"Zeynep","family":"Karahalilo\u011flu","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science Aksaray University  Aksaray 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