{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:52:28Z","timestamp":1788299548610,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["108.05\u20102021.06"],"award-info":[{"award-number":["108.05\u20102021.06"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antimicrobial peptides (AMPs) represent promising scaffolds for therapeutic development, but many natural sequences show limited potency or poor selectivity. Among them,\n                    <jats:bold>Cn\u2010AMP1<\/jats:bold>\n                    , a coconut\u2010derived peptide, exhibits excellent biocompatibility but weak antibacterial and anticancer activities owing to low hydrophobicity and minimal cationic charge. Here, we rationally designed a series of\n                    <jats:bold>Cn\u2010AMP1<\/jats:bold>\n                    derivatives with systematic modulation of charge and hydrophobicity to probe structure\u2013activity relationships. Among them,\n                    <jats:bold>CAP10<\/jats:bold>\n                    , displayed 2\u20134\u2010fold stronger antibacterial potency than earlier analogs while maintaining hemolysis below 10%.\n                    <jats:bold>CAP10<\/jats:bold>\n                    also achieved measurable cytotoxicity toward cancer cells, representing a clear improvement over the other\n                    <jats:bold>Cn\u2010AMP1<\/jats:bold>\n                    derivatives. Molecular dynamics simulations revealed that\n                    <jats:bold>CAP10<\/jats:bold>\n                    penetrates deeply into bacterial and cancer membranes, inducing local bilayer thinning and density depletion, whereas\n                    <jats:bold>Cn\u2010AMP1<\/jats:bold>\n                    remained surface\u2010bound with limited disruption. These results establish that simultaneous optimization of hydrophobicity and charge enhances membrane\u2010active selectivity and dual functionality. Our findings provide structural principles for the rational design of next\u2010generation AMPs with improved efficacy and safety profiles.\n                  <\/jats:p>","DOI":"10.1002\/bip.70068","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:10:01Z","timestamp":1764771001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural Optimization of Cn\u2010\n                    <scp>AMP1<\/scp>\n                    Enhances Antibacterial and Anticancer Potency With Low Hemolysis"],"prefix":"10.1002","volume":"117","author":[{"given":"Hai Bui Thi","family":"Phuong","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Phenikaa University  Hanoi Vietnam"},{"name":"Faculty of Biotechnology Chemistry and Environmental Engineering, Phenikaa University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Ngoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Nguyen Tat Thanh University Center for Hi\u2010Tech Development, Saigon Hi\u2010Tech Park  Ho Chi Minh City Vietnam"},{"name":"NTT Hi\u2010tech Institute, Nguyen Tat Thanh University  Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huyen Ha","family":"Thi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Phenikaa University  Hanoi Vietnam"},{"name":"Faculty of Pharmaceutical Chemistry and Technology, Hanoi University of Pharmacy  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yeungnam University  Gyeongsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong\u2010Thao","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Chemistry and Technology, Hanoi University of Pharmacy  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thang Nguyen","family":"Quoc","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Chemistry and Technology, Hanoi University of Pharmacy  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8729-7377","authenticated-orcid":false,"given":"Van\u2010Duong","family":"Dao","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology Chemistry and Environmental Engineering, Phenikaa University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-8324","authenticated-orcid":false,"given":"Le Minh","family":"Bui","sequence":"additional","affiliation":[{"name":"Nguyen Tat Thanh University Center for Hi\u2010Tech Development, Saigon Hi\u2010Tech Park  Ho Chi Minh City Vietnam"},{"name":"NTT Hi\u2010tech Institute, Nguyen Tat Thanh University  Ho Chi 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