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This study demonstrates the green synthesis of silver nanoparticles (AgNPs) using\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aloe vera<\/jats:italic>\n                    <\/jats:styled-content>\n                    (L.) Burm.f. extract and their incorporation into an Eri silk fibroin (ESF) film to create a novel antimicrobial biomaterial. The AgNPs and the resulting composite films were characterized via UV\u2013Vis, FTIR, and SEM\u2013EDX analyses. Incorporating the green\u2010synthesized AgNPs significantly enhanced the film's physical properties, resulting in high porosity (up to 88.46%) and an optimal water vapor transmission rate (2503.19\u2009g\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day). The final ESF\u2010AVAg composite film exhibited potent, broad\u2010spectrum antimicrobial activity. Specifically, the Zone of Inhibition (ZOI) area for the optimal concentration (AVAg6) was 13.00\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , 13.69\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and 17.55\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , significantly outperforming the controls. This work successfully bridges sustainable green synthesis with biomaterial engineering, demonstrating that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aloe vera<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010derived AgNPs can be effectively integrated into a silk fibroin matrix to produce a high\u2010performance antimicrobial film.\n                  <\/jats:p>","DOI":"10.1002\/bip.70078","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:34:06Z","timestamp":1767872046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of Antimicrobial Films Using Eri Silk Fibroin Blended With Green\u2010Synthesized Silver Nanoparticles Against Common Human Pathogens"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7231-059X","authenticated-orcid":false,"given":"Anbuchezhiyan","family":"Sneka","sequence":"first","affiliation":[{"name":"Department of Entomology, Faculty of Agriculture Annamalai University  Chidambaram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8476-7502","authenticated-orcid":false,"given":"Raghavendra Baregundi","family":"Subbarao","sequence":"additional","affiliation":[{"name":"Horticulture and Molecular Physiology Lab, Department of Horticulture and Food Science School of Agricultural Innovations and Advanced Learning, Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-2240","authenticated-orcid":false,"given":"Thirunavukkarasu","family":"Selvamuthukumaran","sequence":"additional","affiliation":[{"name":"Department of Entomology, Faculty of Agriculture Annamalai University  Chidambaram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-772X","authenticated-orcid":false,"given":"Sowbiya","family":"Muneer","sequence":"additional","affiliation":[{"name":"Horticulture and Molecular Physiology Lab, Department of Horticulture and Food Science School of Agricultural Innovations and Advanced Learning, Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12080735"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12183"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000436849.79161.a4"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40472-024-00453-5"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040789"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2018_226"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA28460D"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2024.113091"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2015.1111232"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11020167"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00576"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.021"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac20a0"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12112701"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.03.041"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.33307\/entomon.v48i4.994"},{"key":"e_1_2_13_18_1","article-title":"Biosynthesis and Antibacterial Activity of Silver Nanoparticles From \n                     Aloe barbadensis","volume":"18","author":"Begum Q.","year":"2020","journal-title":"Iranian Journal of Biotechnology"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-016-1725-x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00540-4"},{"key":"e_1_2_13_21_1","volume-title":"Principles of Instrumental Analysis","author":"Skoog D. 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