{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:05:54Z","timestamp":1760141154467,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T00:00:00Z","timestamp":1155772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotech &amp;amp; Bioengineering"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present paper addresses the numerical optimization of geometrical parameters of non\u2010Newtonian micro\u2010scale viscous pumps for biomedical devices. The objective is to maximize the mass flow rate per unit of shaft power consumed by the rotor when an external pressure load is applied along the channel that houses the rotor. Two geometric parameters are considered in the optimization process: (i) the height of the channel that houses the rotor (<jats:italic>H<\/jats:italic>) and (ii), the eccentricity (<jats:italic>\u03b5<\/jats:italic>) of the rotor. Three different micro\u2010scale viscous pump configurations were tested: a straight\u2010housed pump (I\u2010shaped housing) and two curved housed pumps (L\u2010 and U\u2010shaped housings). The stress\u2013strain constitutive law is modeled by a power\u2010law relation. The results show that the geometric optimization of micro\u2010scale viscous pumps is critical since the mass flow rate propelled by the rotor is highly dependent on <jats:italic>\u03b5<\/jats:italic> and <jats:italic>H<\/jats:italic>. Numerical simulations indicate that mass flow rate is maximized when \u03b5\u2009\u223c\u20090, namely when the rotor is placed at a distance of 0.05 radii from the lower wall. The results also show that micro\u2010scale viscous pumps with curved housing provide higher mass flow rate per unit of shaft power consumed when compared with straight\u2010housed pumps. The results are presented in terms optimized dimensions of all three configurations (i.e., <jats:italic>H<\/jats:italic><jats:sub>opt<\/jats:sub> and <jats:italic>\u03b5<\/jats:italic><jats:sub>opt<\/jats:sub>) and for values of the power\u2010law index varying between 0.5 (shear thinning fluids) and 1.5 (shear\u2010thickening fluids). Biotechnol. Bioeng. 2007;96: 37\u201347. \u00a9 2006 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bit.21165","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T20:23:38Z","timestamp":1155846218000},"page":"37-47","source":"Crossref","is-referenced-by-count":17,"title":["Optimal design of non\u2010Newtonian, micro\u2010scale viscous pumps for biomedical devices"],"prefix":"10.1002","volume":"96","author":[{"given":"A.K.","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.H.","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.F.M.","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10893950490516901"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1949639"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac020239t"},{"volume-title":"Transport phenomena","year":"2001","author":"Bird RB","key":"e_1_2_1_5_1"},{"key":"e_1_2_1_6_1","unstructured":"COMSOL MultiPhysics Inc.2005.User's manual Los Angeles CA 90024."},{"key":"e_1_2_1_7_1","article-title":"Optimal design of viscous micro\u2010scale pumps for maximal mass flow rate and minimum power consumption","author":"da Silva AK","year":"2006","journal-title":"Int J Heat Fluid Flow"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10618569808961670"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2822013"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.09.016"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/0964-1726\/10\/6\/301"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0960-1317\/14\/6\/R01"},{"key":"e_1_2_1_13_1","first-page":"399","volume-title":"Micropropulsion for small spacecraft","author":"Micci MM","year":"2000"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/fld.1124"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1459075"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2005.04.001"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0202435"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2817807"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2819144"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2830071"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200203)23:5<677::AID-ELPS677>3.0.CO;2-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1976-13307"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4005(04)00108-X"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.09.001"}],"container-title":["Biotechnology and Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbit.21165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bit.21165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:09:06Z","timestamp":1760054946000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bit.21165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,17]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/bit.21165"],"URL":"https:\/\/doi.org\/10.1002\/bit.21165","archive":["Portico"],"relation":{},"ISSN":["0006-3592","1097-0290"],"issn-type":[{"type":"print","value":"0006-3592"},{"type":"electronic","value":"1097-0290"}],"subject":[],"published":{"date-parts":[[2006,8,17]]}}}