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We are developing an extracorporeal\u2010specific antibody filter (SAF) as an immunoadsorption device for direct removal of ABO blood group antibodies from whole blood, without the need for plasma separation and plasma exchange. A hollow fiber\u2010based small scale SAF (mini\u2010SAF) device was fabricated and synthetic A antigen, Atrisaccharide (Atri) conjugated to activated polyacrylic acid, was immobilized on the fiber lumen surface. Monoclonal antibody anti\u2010A IgM were specifically removed up to 70% of initial antibodies using mini\u2010SAF device. The monoclonal anti\u2010A capture experiments on mini\u2010SAF indicated that antibody removal relative to the initial concentration is independent of inlet concentration in the beginning; however, as the surface starts saturating with bound antibodies, removal becomes dependent on inlet concentration. No significant effect of flow rate on removal rate was observed. The radial diffusion and axial convection\u2010based mathematical model developed for unsteady state antibody removal was in good agreement with the experimental data and showed that the antibody removal rate can be maximized by increasing the antibody\u2010binding capacity of the SAF. Biotechnol. Bioeng. 2008;99: 876\u2013883. \u00a9 2007 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bit.21621","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T13:20:28Z","timestamp":1187356828000},"page":"876-883","source":"Crossref","is-referenced-by-count":4,"title":["Monoclonal anti\u2010A antibody removal by synthetic A antigen immobilized on specific antibody filters"],"prefix":"10.1002","volume":"99","author":[{"given":"Shalini","family":"Gautam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Y.","family":"Korchagina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai V.","family":"Bovin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Federspiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,25]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"467","article-title":"Sebastian A Compatible ABO mismatch and liver transplantation: A single center's experience","volume":"4","author":"Aladag M","year":"2006","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_1_3_1","first-page":"231","article-title":"Human ABO\u2010incompatible living donor renal homografts","volume":"28","author":"Alexandre GP","year":"1985","journal-title":"Neth J Med"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199905270-00005"},{"key":"e_1_2_1_5_1","first-page":"4543","article-title":"Experiences with known ABO\u2010mismatched renal transplants","volume":"19","author":"Bannett AD","year":"1987","journal-title":"Transplant Proc"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199305000-00006"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006963717646"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00737711"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2509(84)85074-5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1997.tb01962.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2006.00293.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2153::AID-ANR16>3.0.CO;2-W"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00452.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000058226.39732.32"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50011"},{"volume-title":"Selective antibody removal from blood, plasma and buffer using hollow fiber\u2010based specific antibody filters","year":"2003","author":"Hout MS","key":"e_1_2_1_16_1"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/bp025796f"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200011000-00010"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00131.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.08.003"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(02)00294-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.10555"},{"key":"e_1_2_1_23_1","first-page":"283","article-title":"Synthesis of spaced trisaccharides with blood group A and B specificity, their fragments, and structural analogs","volume":"18","author":"Korchagina E","year":"1992","journal-title":"Bioorg Chem"},{"key":"e_1_2_1_24_1","first-page":"375","article-title":"Plasmapheresis. 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