{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:18:37Z","timestamp":1792271917248,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Auvergne Region"},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"OSEO-BpiFrance"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotech &amp;amp; Bioengineering"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>For ethical, regulatory, and economic reasons, in vitro human digestion models are increasingly used as an alternative to in vivo assays. This study aims to present the new Engineered Stomach and small INtestine (ESIN) model and its validation for pharmaceutical applications. This dynamic computer\u2010controlled system reproduces, according to in vivo data, the complex physiology of the human stomach and small intestine, including pH, transit times, chyme mixing, digestive secretions, and passive absorption of digestion products. Its innovative design allows a progressive meal intake and the differential gastric emptying of solids and liquids. The pharmaceutical behavior of two model drugs (paracetamol immediate release form and theophylline sustained release tablet) was studied in ESIN during liquid digestion. The results were compared to those found with a classical compendial method (paddle apparatus) and in human volunteers. Paracetamol and theophylline tablets showed similar absorption profiles in ESIN and in healthy subjects. For theophylline, a level A in vitro\u2013in vivo correlation could be established between the results obtained in ESIN and in humans. Interestingly, using a pharmaceutical basket, the swelling and erosion of the theophylline sustained release form was followed during transit throughout ESIN. ESIN emerges as a relevant tool for pharmaceutical studies but once further validated may find many other applications in nutritional, toxicological, and microbiological fields. Biotechnol. Bioeng. 2016;113: 1325\u20131335. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bit.25890","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T02:56:42Z","timestamp":1448852202000},"page":"1325-1335","source":"Crossref","is-referenced-by-count":60,"title":["Development and validation of a new dynamic computer\u2010controlled model of the human stomach and small intestine"],"prefix":"10.1002","volume":"113","author":[{"given":"Aur\u00e9lie","family":"Guerra","sequence":"first","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Denis","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"le Goff","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sicardi","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Protolab Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Fran\u00e7oise","family":"Yao","sequence":"additional","affiliation":[{"name":"UMR 6620 Laboratoire de Math\u00e9matiques Clermont Universit\u00e9 Universit\u00e9 Blaise Pascal Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain","family":"Garrait","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9 Pacifique","family":"Manzi","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Beyssac","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Alric","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. Dunant F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Blanquet\u2010Diot","sequence":"additional","affiliation":[{"name":"EA 4678 Conception Ing\u00e9nierie et D\u00e9veloppement de l'Aliment et du M\u00e9dicament Clermont Universit\u00e9 Universit\u00e9 d'Auvergne Centre de Recherche en Nutrition Humaine Auvergne Facult\u00e9 de Pharmacie 28 Place H. 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