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This technique has been extensively developed during the past few years, with the main purpose of minimizing the complications arising from the standard protocols used in organ transplantation. By using a variety of strategies used in tissue engineering and regenerative medicine, pancreatic islets have been successfully introduced in host patients with different outcomes in terms of islet survival and functionality, as well as the desired normoglycemic control. Here, we describe and discuss those strategies to transplant islets together with different scaffolds, in combination with various cell types and diffusible factors, and always with the aim of reducing host immune response and achieving islet survival, regardless of the site of transplantation.<\/jats:p>","DOI":"10.1002\/bit.26821","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T05:05:50Z","timestamp":1535173550000},"page":"3009-3029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Tissue\u2010engineering approaches in pancreatic islet transplantation"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8242-5365","authenticated-orcid":false,"given":"Marcos","family":"Perez\u2010Basterrechea","sequence":"first","affiliation":[{"name":"Unidad de Terapia Celular y Medicina Regenerativa, Servicio de Hematolog\u00eda y Hemoterapia, Hospital Universitario Central de Asturias (HUCA) Oviedo Spain"},{"name":"Plataforma de Terapias Avanzadas, Instituto de Investigaci\u00f3n Biosanitaria del Principado de Asturias (ISPA) Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel M.","family":"Esteban","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional Universidad de Oviedo Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-0018","authenticated-orcid":false,"given":"Jose A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular Universidad de Oviedo Oviedo Spain"},{"name":"Facultad de Ciencias de la Salud Universidad Aut\u00f3noma de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4163-2173","authenticated-orcid":false,"given":"Alvaro J.","family":"Obaya","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional Universidad de Oviedo Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(01)01918-2"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2007.0435"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.1.S192"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000129112"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199601000-00014"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401423"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1613959"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.02.036"},{"issue":"2","key":"e_1_2_5_1_10_1","first-page":"111","article-title":"The incorporation of extracellular matrix proteins in protein polymer hydrogels to improve encapsulated beta\u2010cell function","volume":"43","author":"Beenken\u2010Rothkopf L. 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