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To overcome limitations on influenza vaccines' availability and effectiveness, researchers chase universal vaccines providing broad, long\u2010lasting protection against multiple influenza subtypes, and including pandemic ones.<\/jats:p><jats:p>Novel influenza vaccine designs are under development, in clinical trials, or reaching the market, namely inactivated, or live\u2010attenuated virus, virus\u2010like particles, or recombinant antigens, searching for improved effectiveness; all these bring downstream processing (DSP) new challenges. Having to deal with new influenza strains, including pandemics, requires shorter development time, driving the development of faster bioprocesses. To cope with better upstream processes, new regulatory demands for quality and safety, and cost reduction requirements, new unit operations and integrated processes are increasing DSP efficiency for novel vaccine formats.<\/jats:p><jats:p>This review covers recent advances in DSP strategies of different influenza vaccine formats. Focus is given to the improvements on relevant state\u2010of\u2010the\u2010art unit operations, from harvest and clarification to purification steps, ending with sterile filtration and formulation. The development of more efficient unit operations to cope with biophysical properties of the new candidates is discussed: emphasis is given to the design of new stationary phases, 3D printing approaches, and continuous processing tools, such as continuous chromatography. 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