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To this effect, an ex vivo study model was employed to assess the behavior of the injected hydrogels\u2014specifically, their surface stiffness and integration strength with the surrounding cartilage. The highest chondrogenic activity was observed from AC\u2010encapsulated hydrogels, while the effect of PLL on MSC chondrogenesis was not apparent from biochemical analyses. Mechanical testing showed that there were no significant differences in either surface stiffness or integration strength among the different study groups. Altogether, the results suggest that the ex vivo model can allow further understanding of the relationship between biochemical changes within the hydrogel and their impact on the hydrogel's mechanical properties.<\/jats:p>","DOI":"10.1002\/bit.27804","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T06:09:25Z","timestamp":1619676565000},"page":"2958-2966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of tissue integration of injectable, cell\u2010laden hydrogels of cocultures of mesenchymal stem cells and articular chondrocytes with an ex vivo cartilage explant model"],"prefix":"10.1002","volume":"118","author":[{"given":"Yu Seon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shail M.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah A.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon T.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry L.","family":"Koons","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Navara","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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