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However, the higher production cost and purification strategies are out of reach for the developing nations. In this scenario, development of edible vaccine turns out to be the most promising alternative for remodeling the pharmaceutical industry with reduced production and purification costs. Generally, oral route of vaccination is mostly preferred due to its safety, compliance, low manufacturing cost and most importantly the ability to induce immunity in both systemic and mucosal sites. Genetically modified microorganisms and plants could efficiently be used as vehicles for edible vaccines. Edible vaccines are supposed to reduce the risk associated with traditional vaccines. Currently, oral vaccines are available in the market for several viral and bacterial diseases like cholera, hepatitis B, malaria, rabies etc. Herein, the review focuses on the breakthrough events in the area of edible vaccines associated with dietary microbes and plants for better control over diseases.<\/jats:p>","DOI":"10.1002\/bit.27987","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T02:24:38Z","timestamp":1636511078000},"page":"327-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Insight of oral vaccines as an alternative approach to health and disease management: An innovative intuition and challenges"],"prefix":"10.1002","volume":"119","author":[{"given":"Nabendu","family":"Debnath","sequence":"first","affiliation":[{"name":"Centre for Molecular Biology Central University of Jammu Samba Jammu &amp; Kashmir (UT) India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Microbiology Central University of Haryana Mahendergarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Khushboo","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Central University of Haryana Mahendergarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam P.","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University Institute of Biotechnology Chandigarh University Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhav","family":"Gautam","sequence":"additional","affiliation":[{"name":"Centre of Experimental Medicine &amp; 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