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With limited demand and supply of effective drugs, researchers rushed to repurpose the existing approved drugs for the treatment of COVID\u201019. The process of drug screening and testing is very costly and requires several steps for validation and treatment efficacy evaluation ranging from in\u2010vitro to in\u2010vivo setups. After these steps, a clinical trial is mandatory for the evaluation of treatment efficacy and side effects in humans. These processes enhance the overall cost and sometimes the lead molecule show adverse effects in humans and the trial ends up in the final stages. Recently with the advent of three\u2010dimensional (3D) organoid culture which mimics the human tissue exactly the process of drug screening and testing can be done in a faster and cost\u2010effective manner. Further 3D organoids prepared from stems cells taken from individuals can be beneficial for personalized drug therapy which could save millions of lives. 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In the end, the key challenges for the wide applicability of human organoids for drug screening with prospects of future orientation have been included.<\/jats:p>","DOI":"10.1002\/bit.28166","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T01:55:13Z","timestamp":1656467713000},"page":"2669-2688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["3D printed human organoids: High throughput system for drug screening and testing in current COVID\u201019 pandemic"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-9405","authenticated-orcid":false,"given":"Arpana","family":"Parihar","sequence":"first","affiliation":[{"name":"Industrial Waste Utilization, Nano and Biomaterials CSIR\u2010Advanced Materials and Processes Research Institute (AMPRI) Bhopal Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasundhara","family":"Pandita","sequence":"additional","affiliation":[{"name":"Department of Biosciences Barkatullah University Bhopal Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Khan","sequence":"additional","affiliation":[{"name":"Industrial Waste Utilization, Nano and Biomaterials CSIR\u2010Advanced Materials and Processes Research Institute (AMPRI) Bhopal Madhya Pradesh India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.06.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2019.107460"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.03.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2004.05.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-00803-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22796"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/app8030412"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.31117\/neuroscirn.v2i1.28"},{"issue":"951","key":"e_1_2_9_10_1","first-page":"1","article-title":"Single luminal epithelial progenitors can generate prostate organoids in culture","volume":"16","author":"Chua C. 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