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Hospitalized influenza patients often have excess interferon production and a dysregulated immune response to the IAV infection. Obtaining a better understanding of the mechanisms of IAV infection that induce these harmful effects would help drug developers and health professionals create more effective treatments for IAV infection and improve patient outcomes. IAV stimulates viral sensors and receptors expressed by alveolar epithelial cells, like RIG\u2010I and toll\u2010like receptor 3 (TLR3). These two pathways coordinate with one another to induce expression of type III interferons to combat the infection. Presented here is a queuing theory\u2010based model of these pathways that was designed to analyze the timing and amount of interferons produced in response to IAV single stranded RNA and double\u2010stranded RNA detection. The model accurately represents biological data showing the necessary coordination of the RIG\u2010I and TLR3 pathways for effective interferon production. This model can serve as the framework for future studies of IAV infection and identify new targets for potential treatments.<\/jats:p>","DOI":"10.1002\/bit.28284","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T07:58:51Z","timestamp":1668499131000},"page":"562-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modeling an immune response to influenza A virus infection in alveolar epithelial cells"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-6245","authenticated-orcid":false,"given":"Marissa L.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Nebraska\u2010Lincoln  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Joint Educational Programs Trudeau Institute  Saranac Lake New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz A.","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Nebraska\u2010Lincoln  Omaha Nebraska USA"},{"name":"Department of Digital Systems UTP University of Science and Technology  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02606-10"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2474"},{"key":"e_1_2_8_4_1","unstructured":"Centers for Disease Control and Prevention. 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