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In addition, the incorporation of photodynamic therapy (PDT) and photothermal therapy (PTT) into one nanosystem presents great promise to defect multiple drawbacks in cancer therapy. Herein, we fabricated a multifunctional and dual\u2010targeting nanoplatform based on hyaluronic acid\u2010grafted\u2010(mPEG\/triethylenetetramine\u2010conjugated\u2010lipoic acid\/tetra(4\u2010carboxyphenyl)porphyrin\/folic acid) polymer ligand capped AuNRs (AuNRs@HA\u2010g\u2010(mPEG\/Teta\u2010co\u2010(LA\/TCPP\/FA)) for combined photodynamic\u2013photothermal therapy of cancer. The prepared nanoparticles displayed high TCPP loading capacity and excellent stability in different biological media. Furthermore, AuNRs@HA\u2010g\u2010(mPEG\/Teta\u2010co\u2010(LA\/TCPP\/FA)) not only could produce a localized hyperthermia to conduct PTT, but also generate cytotoxic singlet oxygen (<jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>) to perform PDT under laser irradiation. Confocal imaging results disclosed that this nanoparticle endowing the specific function of polymeric ligand could enhance cellular uptake, accelerate endo\/lysosomal escape, as well as produce higher reactive oxygen species. Importantly, this combination therapy strategy could also induce higher anticancer potential than PDT or PTT only against MCF\u20107 tumor cells in vitro. Therefore, this work presented an AuNRs\u2010based therapeutic nanoplatform with great potential in dual\u2010targeting and photo\u2010induced combination therapy of cancer.<\/jats:p>","DOI":"10.1002\/bit.28462","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T05:39:56Z","timestamp":1686202796000},"page":"2333-2344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dual\u2010targeting multifunctional hyaluronic acid ligand\u2010capped gold nanorods with enhanced endo\u2010lysosomal escape ability for synergetic photodynamic\u2013photothermal therapy of cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Xin Jun","family":"Xu","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Jilin Institute of Chemical Technology  Jilin City Jilin Province 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Jilin Institute of Chemical Technology  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Jilin Institute of Chemical Technology  Jilin City Jilin Province 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