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P450s are considered useful biocatalysts for the production of pharmaceutical products, fine chemicals, and bioremediating agents. Despite having tremendous biotechnological potential, being heme\u2010monooxygenases, P450s require either autologous or heterologous redox partner(s) to perform chemical transformations. Randomly distributed P450s throughout a bacterial genome and devoid of particular redox partners in natural products biosynthetic gene clusters (BGCs) showed an extra challenge to reveal their pharmaceutical potential. However, continuous efforts have been made to understand their involvement in antibiotic biosynthesis and their modification, and this review focused on such BGCs. Here, particularly, we have discussed the role of P450s involved in the production of macrolides and aminocoumarin antibiotics, nonribosomal peptide\u00a0(NRPSs) antibiotics, ribosomally synthesized and post\u2010translationally modified peptide\u00a0(RiPPs) antibiotics, and others. Several reactions catalyzed by P450s, as well as the role of their redox partners involved in the BGCs of various antibiotics and their derivatives, have been primarily addressed in this review, which would be useful in further exploration of P450s for the biosynthesis of new therapeutics.<\/jats:p>","DOI":"10.1002\/bit.28548","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:29:40Z","timestamp":1694392180000},"page":"3465-3492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biocatalytic role of cytochrome P450s to produce antibiotics: A review"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4087-1487","authenticated-orcid":false,"given":"Anup","family":"Adhikari","sequence":"first","affiliation":[{"name":"Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3998-0718","authenticated-orcid":false,"given":"Sajan","family":"Shakya","sequence":"additional","affiliation":[{"name":"Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-2069","authenticated-orcid":false,"given":"Shreesti","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal"},{"name":"Department of Chemistry and Biochemistry Miami University Oxford Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-0655","authenticated-orcid":false,"given":"Dipa","family":"Aryal","sequence":"additional","affiliation":[{"name":"Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1508-7060","authenticated-orcid":false,"given":"Kavi Prasad","family":"Timalsina","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, National College Tribhuvan University Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-8263","authenticated-orcid":false,"given":"Dipesh","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-7679","authenticated-orcid":false,"given":"Yogan","family":"Khatri","sequence":"additional","affiliation":[{"name":"Cayman Chemical Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-6489","authenticated-orcid":false,"given":"Niranjan","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c10361"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00180a039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB01023E"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00365"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.07.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(00)00038-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00016-06"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9QO01328H"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/np4001224"},{"key":"e_1_2_9_11_1","first-page":"171","volume-title":"Methods in enzymology","author":"Barry S. 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