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Despite antibiotics, access to clean water and vaccination are the most economically affordable options to prevent those infections and their health consequences. Vaccines, such as those approved for rotavirus and cholera, have played a key role in preventing several enteric diseases. However, vaccines for other pathogens are still in clinical trials. Distribution and cost remain significant barriers to vaccine access in developing regions due to poor healthcare infrastructure, cold\u2010chain requirements, and high production costs. Plant\u2010made vaccines offer a promising alternative to address these challenges. Plants can be easily grown, lowering production costs, and can be administered in oral forms, potentially eliminating cold\u2010chain dependency. Although there are some promising prototypes of vaccines produced in plants, challenges remain, including yields and achieving sufficient immunogenicity. This review aims to describe common enteric pathogens and available vaccines, followed by a strategic summary of plant\u2010made vaccine development and a discussion of plant\u2010made enteric vaccine prototypes. Trends to overcome the key challenges for plant\u2010made vaccines are identified and placed in perspective for the development of affordable and effective vaccines for populations at the highest risk of enteric diseases.<\/jats:p>","DOI":"10.1002\/bit.28876","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:54:55Z","timestamp":1733118895000},"page":"457-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plant\u2010Made Vaccines Targeting Enteric Pathogens\u2014Safe Alternatives for Vaccination in Developing Countries"],"prefix":"10.1002","volume":"122","author":[{"given":"Edgar","family":"Trujillo","sequence":"first","affiliation":[{"name":"Immunology &amp; Vaccinology Group. Centro de Investigaciones Biol\u00f3gicas del Noroeste, S.C. (CIBNOR). Instituto Polit\u00e9cnico Nacional 195, Playa Palo de Santa Rita Sur La Paz, B.C.S. 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