{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:55:39Z","timestamp":1772517339493,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech &amp;amp; Bioengineering"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ultraviolet\u2010B (UVB) radiation exacerbates oxidative stress, accelerating collagen degradation and skin aging. While collagen and its hydrolysates offer therapeutic potential, medical apparatus and instruments call for high quality and traceability. Here we investigated the synergistic effects of collagen and collagen peptides derived from Shad (\n                    <jats:italic>Alosa sapidissima<\/jats:italic>\n                    ) scales against UVB\u2010induced skin damage. Collagen was extracted and peptides were obtained through enzymatic hydrolysis. Structural characterization confirmed collagen's triple helix and peptide fragments. In vitro assays demonstrated concentration\u2010dependent antioxidant activity: collagen peptides (5%\u201310%) and collagen (0.5%\u20131%) exhibited potent DPPH\/ABTS\u207a radical scavenging, with their combination outperforming individual components. In UVB\u2010irradiated mice, topical application of the collagen\u2010peptide mixture significantly reduced epidermal thickening, suppressed ROS production, and enhanced SOD activity. Histological analysis revealed mitigated wrinkle formation and improved dermal blood flow. The mixture also formed stable hydrogels, enhancing bioavailability. These findings highlight the dual mechanism of collagen (structural support) and peptides (antioxidant\/moisturizing effects), offering a promising strategy for combating photoaging. This study provides foundational insights for developing marine collagen\u2010based dermatological therapies.\n                  <\/jats:p>","DOI":"10.1002\/bit.70099","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T05:50:47Z","timestamp":1762408247000},"page":"486-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Collagen and Collagen Peptide From the\n                    <i>Alosa Sapidissima<\/i>\n                    Protect Against UVB\u2010Induced Skin Damage"],"prefix":"10.1002","volume":"123","author":[{"given":"Jinjia","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery The Second Affiliated Hospital of Soochow University, Suzhou Medical College, Soochow University Suzhou Jiangsu Province 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