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Conventional biological control agents (BCAs), while environmentally friendly, often suffer environmental challenges and secretion of limited\/poor antimicrobial compounds. Advances in CRISPR\/Cas genome editing, protease engineering, and synthetic biology have enabled precise modifications that improve pathogen targeting and secretion efficiency. Interest should now be shifted on development of \u201cSuper Bioagents (SBs)\u201d with enhanced secretion systems (SSs) for plant disease suppression against changing environmental factors. This will create sustainable ecofriendly alternative to chemical pesticides. This review explores a detailed overview of molecular mechanisms of microbial SSs and the potentials of SBs as a frontier in plant disease management. While there are still challenges in mass deployment of BCAs in sustainable agriculture, this review is guided by the hypothesis that rational,\u00a0quantitative engineering of microbial SSs can transform conventional BCAs into integrated SBs. It synthesizes current advances within a systems\u2011level bioengineering framework linking secretion efficiency, regulation, and field performance. It further explores possible integration of SBs in plant\u2013microbiome interactions to further enhance their adaptability and effectiveness. Finally, the review dives into recent breakthroughs, current challenges, and future directions for SBs development and application as\u00a0next\u2010generation plant disease control agents.<\/jats:p>","DOI":"10.1002\/bit.70303","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T19:12:05Z","timestamp":1783883525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-1251","authenticated-orcid":false,"given":"Michael Dare","family":"Asemoloye","sequence":"first","affiliation":[{"name":"Department of Biological &amp; Environmental Sciences Walter Sisulu University Mthatha Eastern Cape South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"issue":"12","key":"e_1_2_12_2_1","first-page":"2","article-title":"Genetics and Metabolic Engineering of Yeast Strain Development for Efficient Ethanol Production","volume":"45","author":"Adebami G.","year":"2021","journal-title":"Journal of Food Processing and Preservation"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology14111505"},{"issue":"6","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3390\/horticulturae9060659","article-title":"Bioresources in Organic Farming: Implications for Sustainable Agricultural Systems","volume":"9","author":"Akanmu A. 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