{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:03:18Z","timestamp":1784624598443,"version":"3.55.0"},"reference-count":210,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech &amp;amp; Bioengineering"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Protein A (SpA), a cell wall\u2010associated protein of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , is an immunoglobulin (Ig) binding molecule with high affinity to the Fc moiety of IgG. It can help\n                    <jats:italic>S. aureus<\/jats:italic>\n                    for effective shielding from recognition and opsonization by immune cells, thereby promoting bacterial immune evasion. Since its recognition in the early 1980s, diverse applications have been developed across biotechnology, medicine, and biochemical research, using both native and recombinant SpA variants produced in various host cells. This review provides a comprehensive overview of the major applications of SpA, with an emphasis on techniques that progressed to commercially available tools\/platforms. These applications are based on its Ig\u2010binding capability, including purification of monoclonal antibodies in biopharmaceutical manufacturing, selective isolation of antibodies in diagnostic workflows, integration into serological assays or biosensor systems, and use as a fusion partner\/tag for capturing recombinant proteins.\n                  <\/jats:p>","DOI":"10.1002\/bit.70307","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:22:08Z","timestamp":1784622128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Applications of Staphylococcal Protein A in Biotechnology and Biomedicine: A Comprehensive Review"],"prefix":"10.1002","author":[{"given":"Shirin","family":"Damough","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Biology Tehran Medical Sciences Islamic Azad University Tehran Iran"},{"name":"Biotechnology Research Center, Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Damough","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology Tehran Medical Sciences Islamic Azad University Tehran Iran"},{"name":"Biotechnology Research Center, Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-9769","authenticated-orcid":false,"given":"Ladan","family":"Mafakher","sequence":"additional","affiliation":[{"name":"Thalassemia &amp; Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Heshmati","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Adeli","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeganeh","family":"Talebkhan","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2020.107632","article-title":"Engineering Staphylococcal Protein A for High\u2010Throughput Affinity Purification of Monoclonal Antibodies","volume":"44","author":"Amritkar V.","year":"2020","journal-title":"Biotechnology Advances"},{"issue":"17","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1007\/s00216-018-1067-x","article-title":"A Versatile and Sensitive Lateral Flow Immunoassay for the Rapid Diagnosis of Visceral Leishmaniasis","volume":"410","author":"Anfossi L.","year":"2018","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"6","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.molimm.2007.10.021","article-title":"S. aureus IgG\u2010Binding Proteins SpA and Sbi: Host Specificity and Mechanisms of Immune Complex Formation","volume":"45","author":"Atkins K. 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