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However, current glucose monitoring technologies have many limitations and are often associated with adherence issues. Therefore, in this review, we considered some recent developments in biosensors using microneedles due to their non\u2010invasive character and interstitial fluid measurement for real\u2010time monitoring. The review highlights the use of nanomaterials in nanotechnology, the microfabrication methods, enzyme immobilization methods, and surface modification methods that lead to increased sensitivity and biocompatibility of the sensors. The review also emphasized the advances in clinical studies and the artifacts related to microneedle sensors, such as biofouling and signal drift. Moreover, the review specifically targeted the use of emerging technologies such as non\u2010enzymatic sensing, multiplex biomarker detection, AI\u2010based analysis, health monitoring, and a closed\u2010loop insulin release system. 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