{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:40:14Z","timestamp":1792395614617,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech &amp; Bioengineering"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Breast cancer remains a major global health challenge, highlighting the need for targeted drug delivery systems with improved therapeutic efficacy and reduced systemic toxicity. In this study, a green\u2010synthesized dual\u2010responsive magnetic nanoplatform, Iron oxide@Tween 80\u2010PEG\u2010ARI\u2010NPs, was developed for targeted breast cancer therapy. Iron oxide nanoparticles were synthesized using\n                    <jats:italic>Nephelium lappaceum<\/jats:italic>\n                    (\n                    <jats:italic>Rambutan<\/jats:italic>\n                    ) peel extract as an eco\u2010friendly reducing and stabilizing agent, followed by functionalization with Tween 80, polyethylene glycol (PEG), and aripiprazole (ARI) loading. Comprehensive characterization using FTIR, XRD, SEM\u2010EDX, HR\u2010TEM, DLS, TGA\/DTA, and VSM confirmed successful surface modification, spherical morphology, preserved crystallinity, superparamagnetic behavior, and enhanced colloidal stability. In vitro drug release studies demonstrated minimal ARI leakage at physiological pH 7.4 and accelerated release under acidic pH 5.5 and oxidative conditions, reaching 70.40%\u2009\u00b1\u20090.55% and 90.35%\u2009\u00b1\u20095.15% cumulative release after 60\u2009h, respectively. Release kinetics followed anomalous non\u2010Fickian diffusion under acidic conditions and quasi\u2010Fickian diffusion at physiological pH. The nanoparticles exhibited significant anti\u2010inflammatory activity and potent cytotoxicity against MCF\u20107 breast cancer cells, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 40.2\u2009\u00b1\u20092.15\u2009\u00b5g\/mL, inducing pronounced apoptotic morphological changes. These findings demonstrate the potential of Iron oxide@Tween 80\u2010PEG\u2010ARI\u2010NPs as an effective dual\u2010responsive magnetic nanocarrier for targeted breast cancer therapy with enhanced therapeutic potential.\n                  <\/jats:p>","DOI":"10.1002\/bit.70382","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:48:48Z","timestamp":1792392528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biogenic Magnetic Nanoplatform for Dual Tumor Microenvironment\u2010Responsive Aripiprazole Delivery in Breast Cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-8225","authenticated-orcid":false,"given":"S.","family":"Ayyanaar","sequence":"first","affiliation":[{"name":"Department of Chemistry KIT\u2010Kalaignarkarunanidhi Institute of Technology Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-4469","authenticated-orcid":false,"given":"Munusamy","family":"Settu","sequence":"additional","affiliation":[{"name":"Centre for Applied Nanomaterials, Chennai Institute of Technology Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arunkumar","sequence":"additional","affiliation":[{"name":"Department of Condensed Matter Physics Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, SIMATS Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kayalvizhi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Eshwar College of Engineering Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sathiyamoorthy","sequence":"additional","affiliation":[{"name":"Department of Physics SSN Research Centre, Sri Sivasubramaniya Nadar College of Engineering Kalavakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnpeter Deepak","family":"Rosario","sequence":"additional","affiliation":[{"name":"School of Mechanical, Sathyabama Institute of Science and Technology Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-8043","authenticated-orcid":false,"given":"M. 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