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Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two\u2010dimensional (2D) cell cultures, fail to adequately replicate the hepatic microenvironment, even when improved by adding additional cell types and extracellular matrix (ECM). These models do not address all necessary key components to mimic in vivo conditions, particularly multicellularity, specific ECM, and proper biophysical and biochemical parameters. Organoids, 3D\u2010bioprinted constructs, and liver\u2010on\u2010chip platforms establish physiologically relevant models by improving cell\u2013cell and cell\u2013matrix interactions and multicellular architecture. For a comprehensive understanding of the liver's interconnections with related tissues and organs, a multi\u2010organ\u2010on\u2010chip is a useful platform for more systemic studies. Also, other interdisciplinary approaches, particularly omics and artificial intelligence (AI), can enhance the accuracy of experimental and pre\u2010clinical data achieved by such advanced in vitro liver platforms. This review highlights developing platforms for integrated approaches in experimental liver studies to enable researchers to have a holistic view of the liver in physiologic and pathologic conditions.<\/jats:p>","DOI":"10.1002\/bit.70411","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:06:27Z","timestamp":1791795987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver\u2010on\u2010Chip to Omics and Artificial Intelligence"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5936-5483","authenticated-orcid":false,"given":"Seyedeh Kiana","family":"Teymorian","sequence":"first","affiliation":[{"name":"Department of Basic Sciences and Advanced Technologies in Biology University of Science and Culture Tehran Iran"},{"name":"Department of Regenerative Medicine, Cell Science Research Center Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6918-4748","authenticated-orcid":false,"given":"Pedram Asadi","family":"Sarabi","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Cell Science Research Center Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-6214","authenticated-orcid":false,"given":"Abbas","family":"Piryaei","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-4366","authenticated-orcid":false,"given":"Massoud","family":"Vosough","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Cell Science Research Center Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"},{"name":"Experimental Cancer Medicine, Institution for Laboratory Medicine Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2022-5892"},{"issue":"19","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.3390\/cancers17193210","article-title":"Spatial Transcriptomics Reveals Distinct Architectures but Shared Vulnerabilities in Primary and Metastatic Liver Tumors","volume":"17","author":"Adapa S. 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