{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:44:52Z","timestamp":1787942692815,"version":"build-2784847793"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":1861,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The lack of uniform criteria for coding of gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) has hampered previous epidemiological studies. The epidemiology of GEP-NEN was investigated in this study using currently available criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients diagnosed with GEP-NEN between January 2003 and December 2013 in a well defined Norwegian population of approximately 350 000 people were included. Age- and sex-adjusted incidence rates were calculated. The current 2010 World Health Organization criteria, European Neuroendocrine Tumour Society classification and International Union Against Cancer (UICC) classification were used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 204 patients (114 male, 55\u00b79 per cent) were identified. The median age at diagnosis was 61 (range 10\u201394) years. The annual overall crude incidence was 5\u00b783 per 100 000 inhabitants, with an increasing trend (P = 0\u00b7033). The most frequent location was small intestine (60 patients, 29\u00b74 per cent) followed by appendix (48 patients, 23\u00b75 per cent) and pancreas (33 patients, 16\u00b72 per cent). Grade 1 tumours were more common in gastrointestinal (100 patients, 58\u00b75 per cent) than in pancreatic (9 patients, 27 per cent) NEN. According to the UICC classification, 77 patients (37\u00b77 per cent) had stage I, 17 patients (8\u00b73 per cent) stage II, 37 patients (18\u00b71 per cent) stage III and 70 patients (34\u00b73 per cent) had stage IV disease. No patient with stage I disease had grade 3 tumours; advanced tumour grade increased with stage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A high crude incidence of GEP-NEN, at 5\u00b783 per 100 000 inhabitants, was noted together with a significant increasing trend over time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10034","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T10:47:01Z","timestamp":1446115621000},"page":"226-232","source":"Crossref","is-referenced-by-count":67,"title":["Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using current coding criteria"],"prefix":"10.1093","volume":"103","author":[{"given":"O M","family":"Sandvik","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Stavanger University Hospital , Stavanger,","place":["Norway"]},{"name":"Department of Clinical Medicine, University of Bergen , Bergen,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"S\u00f8reide","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Stavanger University Hospital , Stavanger,","place":["Norway"]},{"name":"Department of Clinical Medicine, University of Bergen , Bergen,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Gudlaugsson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stavanger University Hospital , Stavanger,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J T","family":"Kval\u00f8y","sequence":"additional","affiliation":[{"name":"Department of Research, Stavanger University Hospital , Stavanger,","place":["Norway"]},{"name":"Department of Mathematics and Natural Sciences, University of Stavanger , Stavanger,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"S\u00f8reide","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Stavanger University Hospital , Stavanger,","place":["Norway"]},{"name":"Department of Clinical Medicine, University of Bergen , Bergen,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"2024092914190272500_bjs10034-bib-0001","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1530\/EJE-12-0418","article-title":"Endocrine tumours: epidemiology of malignant digestive neuroendocrine tumours","volume":"168","author":"Lepage","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"2024092914190272500_bjs10034-bib-0002","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \u2018carcinoid\u2019: epidemiology of and prognostic factors for neuroendocrine tumors in 35 825 cases in the United States","volume":"26","author":"Yao","year":"2008","journal-title":"J Clin Oncol"},{"key":"2024092914190272500_bjs10034-bib-0003","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1196\/annals.1294.002","article-title":"The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification","volume":"1014","author":"Kl\u00f6ppel","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"2024092914190272500_bjs10034-bib-0004","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/BF02114017","article-title":"\u00dcber einen Dr\u00fcsenpolyp im Ileum","volume":"38","author":"Langhans","year":"1867","journal-title":"Archiv F Pathol Anat"},{"key":"2024092914190272500_bjs10034-bib-0005","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0140-6736(63)90951-6","article-title":"The classification of carcinoid tumours","volume":"1","author":"Williams","year":"1963","journal-title":"Lancet"},{"key":"2024092914190272500_bjs10034-bib-0006","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/1097-0142(1971)28:4<990::AID-CNCR2820280424>3.0.CO;2-K","article-title":"Pathologic analysis of carcinoids. 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