{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:27:38Z","timestamp":1792193258660,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T00:00:00Z","timestamp":1453075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Complete mesocolic excision (CME) seems to be associated with improved oncological outcomes compared with \u2018conventional\u2019 surgery, but there is a potential for higher morbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data for patients after elective resection at the four centres in the Capital Region of Denmark (June 2008 to December 2013) were retrieved from the Danish Colorectal Cancer Group database and medical charts. Approval from a Danish ethics committee was not required (retrospective study).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 529 patients who underwent CME surgery at one centre were compared with 1701 patients undergoing \u2018conventional\u2019 resection at the other three hospitals. Laparoscopic CME was performed in 258 (48\u00b78 per cent) and laparoscopic \u2018conventional\u2019 resection in 1172 (68\u00b79 per cent). More extended right colectomy procedures were done in the CME group (17\u00b74 versus 3\u00b76 per cent). The 90-day mortality rate in the CME group was 6\u00b72 per cent versus 4\u00b79 per cent in the \u2018conventional\u2019 group (P = 0\u00b7219), with a propensity score-adjusted logistic regression odds ratio (OR) of 1\u00b722 (95 per cent c.i. 0\u00b779 to 1\u00b787). Laparoscopic surgery was associated with a lower risk of mortality at 90 days (OR 0\u00b763, 0\u00b742 to 0\u00b795). Intraoperative injury to other organs was more common in CME operations (9\u00b71 per cent versus 3\u00b76 per cent for \u2018conventional\u2019 resection; P &amp;lt; 0\u00b7001), including more splenic (3\u00b72 versus 1\u00b72 per cent; P = 0\u00b7004) and superior mesenteric vein (1\u00b77 versus 0\u00b72 per cent; P &amp;lt; 0\u00b7001) injuries. Rates of sepsis with vasopressor requirement (6\u00b76 versus 3\u00b72 per cent; P = 0\u00b7001) and postoperative respiratory failure (8\u00b71 versus 3\u00b74 per cent; P &amp;lt; 0\u00b7001) were higher in the CME group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CME is associated with more intraoperative organ injuries and severe non-surgical complications than \u2018conventional\u2019 resection for colonic cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10083","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T15:07:51Z","timestamp":1453129671000},"page":"581-589","source":"Crossref","is-referenced-by-count":188,"title":["Short-term outcomes after complete mesocolic excision compared with \u2018conventional\u2019 colonic cancer surgery"],"prefix":"10.1093","volume":"103","author":[{"given":"C A","family":"Bertelsen","sequence":"first","affiliation":[{"name":"Department of Surgery, Hiller\u00f8d University Hospital, University of Copenhagen, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A U","family":"Neuenschwander","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiller\u00f8d University Hospital, University of Copenhagen, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiller\u00f8d University Hospital, University of Copenhagen, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kirkegaard-Klitbo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev University Hospital, University of Copenhagen, Herlev, Denmark"},{"name":"Department of Surgery, K\u00f8ge Roskilde University Hospital, University of Copenhagen, K\u00f8ge, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Tenma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bispebjerg University Hospital, University of Copenhagen, K\u00f8benhavn, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Wilhelmsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiller\u00f8d University Hospital, University of Copenhagen, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L V","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiller\u00f8d University Hospital, University of Copenhagen, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Herlev University Hospital, University of Copenhagen, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"G\u00f6genur","sequence":"additional","affiliation":[{"name":"Department of Surgery, K\u00f8ge Roskilde University Hospital, University of Copenhagen, K\u00f8ge, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Bols","sequence":"additional","affiliation":[{"name":"Department of Pathology, Herlev University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ingeholm","sequence":"additional","affiliation":[{"name":"Department of Pathology, Herlev University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E R","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiller\u00f8d University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Danish Colorectal Cancer Group (DCCG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,1,18]]},"reference":[{"key":"2021021915083607800_bjs10083-bib-0001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1470-2045(14)71168-4","article-title":"Disease-free survival after complete mesocolic excision compared with conventional colon cancer surgery: a retrospective, population-based study","volume":"16","author":"Bertelsen","year":"2015","journal-title":"Lancet Oncol"},{"key":"2021021915083607800_bjs10083-bib-0002","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1463-1318.2010.02474.x","article-title":"Can the quality of colonic surgery be improved by standardization 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