{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:25:41Z","timestamp":1790025941614,"version":"4.0.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Yongang Foundation, Republic of Korea","award":["30-2013-0110"],"award-info":[{"award-number":["30-2013-0110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no consensus on the best method of preventing postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD). This multicentre, parallel group, randomized equivalence trial investigated the effect of two ways of pancreatic stenting after PD on the rate of POPF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing elective PD or pylorus-preserving PD with duct-to-mucosa pancreaticojejunostomy were enrolled from four tertiary referral hospitals. Randomization was stratified according to surgeon with a 1 : 1 allocation ratio to avoid any related technical factors. The primary endpoint was clinically relevant POPF rate. Secondary endpoints were nutritional index, remnant pancreatic volume, long-term complications and quality of life 2 years after PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 328 patients were randomized to the external (164 patients) or internal (164) stent group between August 2010 and January 2014. The rates of clinically relevant POPF were 24\u00b74 per cent in the external and 18\u00b79 per cent in the internal stent group (risk difference 5\u00b75 per cent). As the 90 per cent confidence interval (\u22122\u00b70 to 13\u00b70 per cent) did not fall within the predefined equivalence limits (\u221210 to 10 per cent), the clinically relevant POPF rates in the two groups were not equivalent. Similar results were observed for patients with soft pancreatic texture and high fistula risk score. Other postoperative outcomes were comparable between the two groups. Five stent-related complications occurred in the external stent group. Multivariable analysis revealed that soft pancreatic texture, non-pancreatic disease and high body mass index (23\u00b73 kg\/m2 or above) predicted clinically relevant POPF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>External stenting after PD was associated with a higher rate of clinically relevant POPF than internal stenting. Registration number: NCT01023594 (https:\/\/www.clinicaltrials.gov).<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.10160","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T09:04:50Z","timestamp":1459760690000},"page":"668-675","source":"Crossref","is-referenced-by-count":87,"title":["Randomized multicentre trial comparing external and internal pancreatic stenting during pancreaticoduodenectomy"],"prefix":"10.1093","volume":"103","author":[{"given":"J-Y","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y R","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-W","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre for Liver Cancer, National Cancer Centre, Gyeonggido, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S E","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chung-Ang University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-S","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"2021021915584045000_bjs10160-bib-0001","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000050193","article-title":"Management of complications after pancreaticoduodenectomy in a high volume centre: results on 150 consecutive patients","volume":"18","author":"Bassi","year":"2001","journal-title":"Dig Surg"},{"key":"2021021915584045000_bjs10160-bib-0002","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/00000658-200012000-00007","article-title":"Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume","volume":"232","author":"Gouma","year":"2000","journal-title":"Ann Surg"},{"key":"2021021915584045000_bjs10160-bib-0003","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/SLA.0b013e3181492c28","article-title":"External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial","volume":"246","author":"Poon","year":"2007","journal-title":"Ann Surg"},{"key":"2021021915584045000_bjs10160-bib-0004","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.surg.2006.07.009","article-title":"Current management of pancreatic fistula after pancreaticoduodenectomy","volume":"140","author":"Aranha","year":"2006","journal-title":"Surgery"},{"key":"2021021915584045000_bjs10160-bib-0005","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1007\/s11605-012-1987-2","article-title":"The impact of internal or external transanastomotic pancreatic duct stents following pancreaticojejunostomy. 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