{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:16Z","timestamp":1786977076535,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy and safety of single-incision laparoscopic colectomy (SILC) for colonic cancer remain unclear. The aim of this study was to determine the outcomes of SILC compared with multiport laparoscopic colectomy (MPLC) for colonic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with histologically proven colonic carcinoma located in the caecum, ascending, sigmoid or rectosigmoid colon, clinically diagnosed as stage 0\u2013III by CT, were eligible for this study. Patients were randomized before surgery and underwent tumour dissection with complete mesocolic excision. Safety analyses were conducted according to randomization groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 200 patients were enrolled and randomized to the MPLC (100 patients) or SILC (100 patients) arm. Surgical outcomes were similar between the MPLC and SILC arms, including duration of operation (mean 162 versus 156 min respectively; P = 0\u00b7273), blood loss (mean 8\u00b78 versus 21\u00b74 ml; P = 0\u00b7102), conversion to open laparotomy (2\u00b70 versus 1\u00b70 per cent; P = 0\u00b7561), reoperation (3\u00b70 versus 3\u00b70 per cent; P = 1\u00b7000), time to first flatus (both median 1 day; P = 0\u00b7155) and postoperative hospital stay (both median 6; P = 0\u00b7372). The total skin incision length was significantly shorter in the SILC arm (mean 4\u00b74 cm versus 6\u00b78 cm in the MPLC arm; P &amp;lt; 0\u00b7001). The median duration of analgesia use was 5 days in the MPLC and 4 days in the SILC arm (P = 0\u00b7485). Overall complication rates were equivalent (15\u00b70 versus 12\u00b70 per cent respecitvely; P = 0\u00b7680).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SILC is not superior to MPLC. Registration number: UMIN000007220 (http:\/\/www.umin.ac.jp\/ctr\/index.htm).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.10212","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T04:52:51Z","timestamp":1470804771000},"page":"1276-1281","source":"Crossref","is-referenced-by-count":69,"title":["Randomized clinical trial of single-incision\n                    <i>versus<\/i>\n                    multiport laparoscopic colectomy"],"prefix":"10.1093","volume":"103","author":[{"given":"J","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Surgery, Yokosuka Kyosai Hospital, Yokosuka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Centre, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Centre, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Centre, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ishibe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"key":"2021021815591041900_bjs10212-bib-0001","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/S0140-6736(02)09290-5","article-title":"Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial","volume":"359","author":"Lacy","year":"2002","journal-title":"Lancet"},{"key":"2021021815591041900_bjs10212-bib-0002","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1056\/NEJMoa032651","article-title":"A comparison of laparoscopically assisted and open colectomy for colon cancer","volume":"350","author":"Clinical Outcomes of Surgical Therapy Study Group","year":"2004","journal-title":"N Engl J Med"},{"key":"2021021815591041900_bjs10212-bib-0003","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/S0140-6736(05)66545-2","article-title":"Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial","volume":"365","author":"Guillou","year":"2005","journal-title":"Lancet"},{"key":"2021021815591041900_bjs10212-bib-0004","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1470-2045(05)70221-7","article-title":"COlon cancer Laparoscopic or Open Resection Study Group (COLOR). Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial","volume":"6","author":"Veldkamp","year":"2005","journal-title":"Lancet Oncol"},{"key":"2021021815591041900_bjs10212-bib-0005","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/SLA.0b013e318155a762","article-title":"Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial","volume":"246","author":"Fleshman","year":"2007","journal-title":"Ann Surg"},{"key":"2021021815591041900_bjs10212-bib-0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0b013e31816a9d65","article-title":"The long-term results of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancer","volume":"248","author":"Lacy","year":"2008","journal-title":"Ann Surg"},{"key":"2021021815591041900_bjs10212-bib-0007","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S1470-2045(08)70310-3","article-title":"Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial","volume":"10","author":"Buunen","year":"2009","journal-title":"Lancet Oncol"},{"key":"2021021815591041900_bjs10212-bib-0008","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/bjs.7160","article-title":"Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer","volume":"97","author":"Jayne","year":"2010","journal-title":"Br J Surg"},{"key":"2021021815591041900_bjs10212-bib-0009","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/SLA.0000000000000499","article-title":"Short-term surgical outcomes from a randomized controlled trial to evaluate laparoscopic and open D3 dissection for stage II\/III colon cancer: Japan Clinical Oncology Group Study JCOG 0404","volume":"260","author":"Yamamoto","year":"2014","journal-title":"Ann Surg"},{"key":"2021021815591041900_bjs10212-bib-0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/DCR.0b013e3181fd48af","article-title":"Single-incision vs straight laparoscopic segmental colectomy: a case-controlled study","volume":"54","author":"Champagne","year":"2011","journal-title":"Dis Colon Rectum"},{"key":"2021021815591041900_bjs10212-bib-0011","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s00464-010-1481-4","article-title":"Single-incision laparoscopic versus conventional laparoscopic right hemicolectomy: a comparison of short-term surgical results","volume":"25","author":"Chen","year":"2011","journal-title":"Surg Endosc"},{"key":"2021021815591041900_bjs10212-bib-0012","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/SLA.0b013e318237826b","article-title":"The short-term outcomes of conventional and single-port laparoscopic surgery for colorectal cancer","volume":"254","author":"Kim","year":"2011","journal-title":"Ann Surg"},{"key":"2021021815591041900_bjs10212-bib-0013","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.surg.2011.07.060","article-title":"Single-incision laparoscopic colectomy for cancer: assessment of oncologic resection and short-term outcomes in a case-matched comparison with standard laparoscopy","volume":"150","author":"Papaconstantinou","year":"2011","journal-title":"Surgery"},{"key":"2021021815591041900_bjs10212-bib-0014","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/SLA.0b013e3182378442","article-title":"Single-incision versus standard multiport laparoscopic colectomy: a multicenter, case-controlled comparison","volume":"255","author":"Champagne","year":"2012","journal-title":"Ann Surg"},{"key":"2021021815591041900_bjs10212-bib-0015","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1111\/j.1463-1318.2011.02825.x","article-title":"Comparison of clinical outcome of single-incision laparoscopic surgery using a simplified access system with conventional laparoscopic surgery for malignant colorectal disease","volume":"14","author":"Lu","year":"2012","journal-title":"Colorectal Dis"},{"key":"2021021815591041900_bjs10212-bib-0016","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00464-011-1833-8","article-title":"Single-incision versus conventional laparoscopic sigmoid colectomy: a case-matched series","volume":"26","author":"Ramos-Valadez","year":"2012","journal-title":"Surg Endosc"},{"key":"2021021815591041900_bjs10212-bib-0017","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1159\/000346044","article-title":"Comparison of short-term surgical outcomes after single-incision laparoscopic versus multiport laparoscopic right colectomy: a two-center, prospective case-controlled study of 100 patients","volume":"29","author":"Velthuis","year":"2012","journal-title":"Dig Surg"},{"key":"2021021815591041900_bjs10212-bib-0018","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1007\/s00464-013-3284-x","article-title":"Feasibility of single-site laparoscopic colectomy with complete mesocolic excision for colon cancer: a prospective case\u2013control comparison","volume":"28","author":"Takemasa","year":"2014","journal-title":"Surg Endosc"},{"key":"2021021815591041900_bjs10212-bib-0019","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00464-015-4371-y","article-title":"Short-term and long-term outcomes of single-incision versus multi-incision laparoscopic resection for colorectal cancer: a propensity-score-matched analysis of 214 cases","volume":"30","author":"Katsuno","year":"2016","journal-title":"Surg Endosc"},{"key":"2021021815591041900_bjs10212-bib-0020","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1245\/s10434-014-4039-1","article-title":"Oncologic outcomes of single-incision versus conventional laparoscopic anterior resection for sigmoid colon cancer: a propensity-score matching analysis","volume":"22","author":"Kim","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"2021021815591041900_bjs10212-bib-0021","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00595-015-1154-y","article-title":"A case-matched comparison of single-incision versus multiport laparoscopic right colectomy for colon cancer","volume":"46","author":"Suzuki","year":"2016","journal-title":"Surg Today"},{"key":"2021021815591041900_bjs10212-bib-0022","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00384-012-1537-0","article-title":"Single-incision laparoscopic colectomy versus conventional multiport laparoscopic colectomy: a meta-analysis of comparative studies","volume":"28","author":"Yang","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"2021021815591041900_bjs10212-bib-0023","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ciresp.2014.11.009","article-title":"Single-port colectomy vs multi-port laparoscopic colectomy. Systematic review and meta-analysis of more than 2800 procedures","volume":"93","author":"Luj\u00e1n","year":"2015","journal-title":"Cir Esp"},{"key":"2021021815591041900_bjs10212-bib-0024","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/bjs.8834","article-title":"Systematic review of single-incision laparoscopic colonic surgery","volume":"99","author":"Fung","year":"2012","journal-title":"Br J Surg"},{"key":"2021021815591041900_bjs10212-bib-0025","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin","year":"2009","edition":"7th"},{"key":"2021021815591041900_bjs10212-bib-0026","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/13645700903492969","article-title":"Skill accreditation system for laparoscopic gastroenterologic surgeons in Japan","volume":"19","author":"Mori","year":"2010","journal-title":"Minim Invasive Ther Allied Technol"},{"key":"2021021815591041900_bjs10212-bib-0027","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.amjsurg.2011.09.005","article-title":"Standard laparoscopic versus single-incision laparoscopic colectomy for cancer: early results of a randomized prospective study","volume":"204","author":"Huscher","year":"2012","journal-title":"Am J Surg"},{"key":"2021021815591041900_bjs10212-bib-0028","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1007\/s00464-012-2262-z","article-title":"Single-incision versus conventional laparoscopic colectomy for colonic neoplasm: a randomized, controlled trial","volume":"26","author":"Poon","year":"2012","journal-title":"Surg Endosc"},{"key":"2021021815591041900_bjs10212-bib-0029","first-page":"CD007635","article-title":"Fast track surgery versus conventional recovery strategies for colorectal surgery","volume-title":"Cochrane Database Syst Rev","author":"Spanjersberg","year":"2011"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.10212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.10212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/103\/10\/1276\/36316995\/bjs10212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/103\/10\/1276\/36316995\/bjs10212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T10:16:43Z","timestamp":1621505803000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/103\/10\/1276-1281\/6136356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,10]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,8,10]]},"published-print":{"date-parts":[[2016,8,24]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.10212","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,8,10]]}}}