{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:39:26Z","timestamp":1788824366495,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Radiofrequency ablation (RFA) is an emerging treatment for primary aldosteronism owing to aldosterone-producing adenoma. Whether RFA could be an alternative treatment to laparoscopic adrenalectomy is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective comparative study in patients with aldosterone-producing adenoma undergoing either laparoscopic adrenalectomy or CT-guided percutaneous RFA between 2004 and 2012. Short-term outcomes and long-term resolution rates of primary aldosteronism (normalized aldosterone to renin ratio), hypokalaemia and hypertension (BP lower than 140\/90 mmHg without antihypertensive medical therapy) were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 63 patients were included, 27 in the laparoscopic adrenalectomy group and 36 in the RFA group. RFA was associated with shorter duration of operation (median 12 versus 124 min; P &amp;lt; 0\u00b7001), shorter hospital stay (2 versus 4 days; P &amp;lt; 0\u00b7001), lower analgesic requirements (13 of 36 versus 23 of 27 patients; P &amp;lt; 0\u00b7001) and earlier resumption of work (median 4 versus 14 days; P = 0\u00b7006). Morbidity rates were similar in the two groups. With median follow-up of 5\u00b77 (range 1\u00b79\u201310\u00b76) years, resolution of primary aldosteronism was seen in 33 of 36 patients treated with RFA and all 27 patients who had laparoscopic adrenalectomy (P = 0\u00b7180). Hypertension was resolved less frequently after treatment with RFA compared with laparoscopic adrenalectomy (13 of 36 versus 19 of 27 patients; P = 0\u00b7007). Hypokalaemia was resolved in all patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>For patients with aldosterone-producing adenoma the efficacy of resolution of primary aldosteronism and hypertension was inferior after treatment with RFA compared with laparoscopic adrenalectomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10219","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T08:22:43Z","timestamp":1470903763000},"page":"1476-1486","source":"Crossref","is-referenced-by-count":47,"title":["Radiofrequency ablation compared with laparoscopic adrenalectomy for aldosterone-producing adenoma"],"prefix":"10.1093","volume":"103","author":[{"given":"S Y","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A P","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P W","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F C","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E K","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"2024052209250445100_bjs10219-bib-0001","first-page":"3","article-title":"Presidential address, part II: primary aldosteronism, a new clinical 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