{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:48:29Z","timestamp":1765079309208},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although health-related quality of life (HRQoL) recovers after surgery for oesophageal cancer in most long-term survivors, one in seven patients experiences a deterioration in HRQoL for reasons yet unknown. The aim of this study was to assess whether co-morbidities diagnosed after surgery influence recovery of HRQoL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients who underwent surgery for cancer of the oesophagus or gastro-oesophageal junction in Sweden between 2001 and 2005 were included. HRQoL was assessed by means of the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-OES18 questionnaires. Repeated-measures ANOVA was used to assess mean differences in HRQoL scores between three co-morbidity status groups (healthy, stable and increased) over time. Probabilities of deterioration in HRQoL were calculated based on marginal probabilities from logistic regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At 5 years' follow-up, 153 (24\u00b78 per cent) of 616 patients were alive and 137 responded to at least two of three questionnaires. The healthy and increased co-morbidity groups showed deterioration in almost all aspects of HRQoL at 6 months after surgery compared with baseline. The increased co-morbidity group also deteriorated in several aspects from 3 to 5 years after surgery. Patients with an increase in co-morbidity did not have a significantly increased probability of deterioration in HRQoL over time compared with healthy or stable patients, except with respect to cognitive function, loss of appetite, choking and coughing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with an increase in co-morbidities after oesophagectomy experience long-term deterioration in HRQoL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10248","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T09:24:35Z","timestamp":1471857875000},"page":"1665-1675","source":"Crossref","is-referenced-by-count":20,"title":["Co-morbidity after oesophageal cancer surgery and recovery of health-related quality of life"],"prefix":"10.1093","volume":"103","author":[{"given":"L","family":"Backemar","sequence":"first","affiliation":[{"name":"Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wikman","sequence":"additional","affiliation":[{"name":"Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Dj\u00e4rv","sequence":"additional","affiliation":[{"name":"Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Johar","sequence":"additional","affiliation":[{"name":"Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lagergren","sequence":"additional","affiliation":[{"name":"Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"2021022313082490000_bjs10248-bib-0001","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1442-2050.2011.01304.x","article-title":"Patterns of operative mortality following esophagectomy","volume":"25","author":"Schieman","year":"2012","journal-title":"Dis Esophagus"},{"key":"2021022313082490000_bjs10248-bib-0002","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.athoracsur.2004.02.034","article-title":"Reducing hospital morbidity and mortality following 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