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Some studies have shown that emergency cholecystectomy during the index admission can reduce length of hospital stay with similar rates of conversion to open surgery, complications and mortality compared with a \u2018delayed\u2019 operation following discharge. Others have reported that cholecystectomy during the index acute admission results in higher morbidity, extended length of stay and increased costs. This study examined the cost-effectiveness of emergency versus delayed cholecystectomy for acute benign gallbladder disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using data from a prospective population-based cohort study examining the outcomes of cholecystectomy in the UK and Ireland, a model-based cost\u2013utility analysis was conducted from the perspective of the UK National Health Service, with a 1-year time horizon for costs and outcomes. Probabilistic sensitivity analysis was used to investigate the impact of parameter uncertainty on the results obtained from the model.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Emergency cholecystectomy was found to be less costly (\u00a34570 versus \u00a34720; \u20ac5484 versus \u20ac5664) and more effective (0\u00b78868 versus 0\u00b78662 QALYs) than delayed cholecystectomy. Probabilistic sensitivity analysis showed that the emergency strategy is more than 60 per cent likely to be cost-effective across willingness-to-pay values for the QALY from \u00a30 to \u00a3100 000 (\u20ac0\u2013120 000).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Emergency cholecystectomy is less costly and more effective than delayed cholecystectomy. This approach is likely to be beneficial to patients in terms of improved health outcomes and to the healthcare provider owing to the reduced costs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/bjs.10317","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T05:18:57Z","timestamp":1476940737000},"page":"98-107","source":"Crossref","is-referenced-by-count":43,"title":["Cost-effectiveness of emergency\n versus<\/i>\n delayed laparoscopic cholecystectomy for acute gallbladder pathology"],"prefix":"10.1093","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7008-4770","authenticated-orcid":false,"given":"A J","family":"Sutton","sequence":"first","affiliation":[{"name":"Health Economics Unit, Leeds Institute of Health Sciences, University of Leeds , Leeds,","place":["UK"]},{"name":"National Institute for Health Research Diagnostic Evidence Co-operative Leeds , 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