{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:33:37Z","timestamp":1771947217154,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Combined oral modified-release oxycodone\u2013naloxone may reduce opioid-induced postoperative gut dysfunction. This study examined the feasibility of a randomized trial of oxycodone\u2013naloxone within the context of enhanced recovery for laparoscopic colorectal resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a single-centre open-label phase II feasibility study, patients received analgesia based on either oxycodone\u2013naloxone or oxycodone. Primary endpoints were recruitment, retention and protocol compliance. Secondary endpoints included a composite endpoint of gut function (tolerance of solid food, low nausea\/vomiting score, passage of flatus or faeces).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty-two patients were screened and 62 randomized (76 per cent); the attrition rate was 19 per cent (12 of 62), leaving 50 patients who received the allocated intervention with 100 per cent follow-up and retention (modified intention-to-treat cohort). Protocol compliance was more than 90 per cent. Return of gut function by day 3 was similar in the two groups: 13 (48 per cent) of 27 in the oxycodone\u2013naloxone group and 15 (65 per cent) of 23 in the control group (95 per cent c.i. for difference \u221210\u00b70 to 40\u00b77 per cent; P = 0\u00b7264). However, patients in the oxycodone\u2013naloxone group had a shorter time to first bowel movement (mean(s.d.) 87(38) h versus 111(37) h in the control group; 95 per cent c.i. for difference 2\u00b73 to 45\u00b74 h, P = 0\u00b7031) and reduced total (oral plus parenteral) opioid consumption (mean(s.d.) 78(36) versus 94(56) mg respectively; 95 per cent c.i. for difference \u221210\u00b72 to 42\u00b78 mg, P = 0\u00b7222).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>High participation, retention and protocol compliance confirmed feasibility. Potential benefits of oxycodone\u2013naloxone in reducing time to bowel movement and total opioid consumption could be tested in a randomized trial. Registration number: NCT02109640 (https:\/\/www.clinicaltrials.gov\/).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10322","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T09:47:25Z","timestamp":1476956845000},"page":"42-51","source":"Crossref","is-referenced-by-count":16,"title":["Randomized open-label phase II study comparing oxycodone\u2013naloxone with oxycodone in early return of gastrointestinal function after laparoscopic colorectal surgery"],"prefix":"10.1093","volume":"104","author":[{"given":"F","family":"Creamer","sequence":"first","affiliation":[{"name":"University of Edinburgh Academic Coloproctology , Edinburgh,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Balfour","sequence":"additional","affiliation":[{"name":"University of Edinburgh Academic Coloproctology , Edinburgh,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nimmo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Western General Hospital , Edinburgh,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Foo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Western General Hospital , Edinburgh,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Norrie","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Randomised Trials, Health Services Research Unit , Foresterhill, Aberdeen,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre for Population Health Sciences, University of Edinburgh Medical School , Edinburgh,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K C","family":"Fearon","sequence":"additional","affiliation":[{"name":"University of Edinburgh Academic Coloproctology , Edinburgh,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Paterson","sequence":"additional","affiliation":[{"name":"University of Edinburgh Academic Coloproctology , Edinburgh,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2024092914071337200_bjs10322-bib-0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.suc.2012.01.010","article-title":"Pathogenesis and clinical and economic consequences of postoperative ileus","volume":"92","author":"Doorly","year":"2012","journal-title":"Surg Clin North 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