{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:56:59Z","timestamp":1789732619631,"version":"4.0.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Laparoscopic 180\u00b0 anterior fundoplication has been shown to achieve similar reflux control to Nissen fundoplication, with fewer side-effects, up to 5 years. However, there is a paucity of long-term follow-up data on this technique and antireflux surgery in general. This study reports 12-year outcomes of a double-blind RCT comparing laparoscopic Nissen versus 180\u00b0 laparoscopic anterior fundoplication for gastro-oesophageal reflux disease (GORD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with proven GORD were randomized to laparoscopic Nissen or 180\u00b0 anterior fundoplication. The 12-year outcome measures included reflux control, dysphagia, gas-related symptoms and patient satisfaction. Measures included scores on a visual analogue scale, a validated Dakkak score for dysphagia and Visick scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the initial 163 patients randomized (Nissen 84, anterior 79), 90 (55\u00b72 per cent) completed 12-year follow-up (Nissen 52, anterior 38). There were no differences in heartburn, dysphagia, gas-related symptoms, patient satisfaction or surgical reintervention rate. Use of acid-suppressing drugs was less common after Nissen than after 180\u00b0 anterior fundoplication: four of 52 (8 per cent) and 11 of 38 (29 per cent) respectively (P = 0\u00b7008). The proportion of patients with absent or only mild symptoms was slightly higher after Nissen fundoplication: 45 of 50 (90 per cent) versus 28 of 38 (74 per cent) (P = 0\u00b7044).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The two surgical procedures provided similar control of heartburn and post-fundoplication symptoms, with similar patient satisfaction and reoperation rates on long-term follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10473","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T16:44:23Z","timestamp":1486140263000},"page":"852-856","source":"Crossref","is-referenced-by-count":35,"title":["Long-term symptom control of gastro-oesophageal reflux disease 12 years after laparoscopic Nissen or 180\u00b0 anterior partial fundoplication in a randomized clinical trial"],"prefix":"10.1093","volume":"104","author":[{"given":"D J","family":"Roks","sequence":"first","affiliation":[{"name":"Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Broeders","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Baigrie","sequence":"additional","affiliation":[{"name":"University of Cape Town and Gastrointestinal Unit, Kingsbury Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"2021070910324065700_bjs10473-bib-0001","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bpg.2013.11.003","article-title":"Laparoscopic surgery for gastro-esophageal acid reflux 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