{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:42:17Z","timestamp":1781628137153,"version":"3.54.5"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"BMBF (Federal Ministry of Education and Research, Germany)","award":["01GH0702"],"award-info":[{"award-number":["01GH0702"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Intra-abdominal drains are frequently used after pancreatic surgery whereas their benefit in other gastrointestinal operations has been questioned. The objective of this meta-analysis was to compare abdominal drainage with no drainage after pancreatic surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PubMed, the Cochrane Library and Web of Science electronic databases were searched systematically to identify RCTs comparing abdominal drainage with no drainage after pancreatic surgery. Two independent reviewers critically appraised the studies and extracted data. Meta-analyses were performed using a random-effects model. Odds ratios (ORs) were calculated to aggregate dichotomous outcomes, and weighted mean differences for continuous outcomes. Summary effect measures were presented together with their 95 per cent confidence intervals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 711 patients from three RCTs were included. The 30-day mortality rate was 2\u00b70 per cent in the drain group versus 3\u00b74 per cent after no drainage (OR 0\u00b768, 95 per cent c.i. 0\u00b726 to 1\u00b779; P = 0\u00b743). The morbidity rate was 65\u00b76 per cent in the drain group and 62\u00b70 per cent in the no-drain group (OR 1\u00b717, 0\u00b786 to 1\u00b760; P = 0\u00b731). Clinically relevant pancreatic fistulas were seen in 11\u00b75 per cent of patients in the drain group and 9\u00b75 per cent in the no-drain group. Reinterventions, intra-abdominal abscesses and duration of hospital stay also showed no significant difference between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pancreatic resection with, or without abdominal drainage results in similar rates of mortality, morbidity and reintervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10505","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T12:22:39Z","timestamp":1490012559000},"page":"660-668","source":"Crossref","is-referenced-by-count":51,"title":["Meta-analysis of prophylactic abdominal drainage in pancreatic surgery"],"prefix":"10.1093","volume":"104","author":[{"given":"F J","family":"H\u00fcttner","sequence":"first","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"},{"name":"Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Probst","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Knebel","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Strobel","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hackert","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M W","family":"B\u00fcchler","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M K","family":"Diener","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"},{"name":"Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"2022100812404751100_bjs10505-bib-0001","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1001\/archsurg.138.12.1310","article-title":"Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy","volume":"138","author":"Buchler","year":"2003","journal-title":"Arch Surg"},{"key":"2022100812404751100_bjs10505-bib-0002","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jamcollsurg.2014.12.031","article-title":"Two thousand consecutive pancreaticoduodenectomies","volume":"220","author":"Cameron","year":"2015","journal-title":"J Am Coll Surg"},{"key":"2022100812404751100_bjs10505-bib-0003","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.surg.2005.05.001","article-title":"International Study Group on Pancreatic Fistula Definition. 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