{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:21:37Z","timestamp":1788520897793,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim was to assess the effects of percutaneous tibial nerve stimulation (PTNS) in the treatment of faecal incontinence (FI) by means of an RCT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients aged over 18 years with FI were included in a multicentre, single-blinded RCT. The primary endpoint was reduction in the median or mean number of FI episodes per week. Secondary endpoints were changes in measures of FI severity, and disease-specific and generic quality of life. Outcomes were compared between PTNS and sham stimulation after 9 weeks of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A higher proportion of patients in the PTNS (13 of 29) than in the sham (6 of 30) group showed a reduction of at least 50 per cent in the median number of FI episodes\/week (incidence rate ratio (IRR) 2\u00b740, 95 per cent c.i. 1\u00b710 to 5\u00b724; P = 0\u00b7028), but not in the mean number of episodes\/week (10 of 29 versus 8 of 30; IRR 1\u00b742, 0\u00b769 to 2\u00b792; P = 0\u00b7347). The absolute median number of FI episodes per week decreased in the PTNS but not in the sham group (IRR 0\u00b766, 0\u00b744 to 0\u00b798; P = 0\u00b7041), as did the mean number (IRR 0\u00b765 (0\u00b745 to 0\u00b797); P = 0\u00b7034). Scores on the Cleveland Clinic Florida faecal incontinence scale decreased significantly in both groups, but more steeply in the PTNS group (mean difference \u20131\u00b73, 95 per cent c.i. \u20132\u00b76 to 0\u00b70; P = 0\u00b7049). The aggregated mental component score of Short Form 36 improved in the PTNS but not in the sham group (mean difference 5\u00b71, 0\u00b75 to 9\u00b76; P = 0\u00b7028).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PTNS may offer a small advantage in the clinical management of FI that is insufficiently responsive to conservative treatment. The key challenge will be to identify patients who may benefit most from this minimally invasive surgical procedure. Registration number: NCT00974909 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10590","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T15:15:30Z","timestamp":1499958930000},"page":"1167-1176","source":"Crossref","is-referenced-by-count":40,"title":["Randomized clinical trial of percutaneous tibial nerve stimulation <i>versus<\/i> sham electrical stimulation in patients with faecal incontinence"],"prefix":"10.1093","volume":"104","author":[{"given":"A A","family":"van der Wilt","sequence":"first","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universit\u00e0 degli Studi di Roma \u2018Sapienza\u2019, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kubis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institut des Maladies de l'Appareil Digestiv, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B P W","family":"van Wunnik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-0607","authenticated-orcid":false,"given":"I","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S O","family":"Breukink","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Lehur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institut des Maladies de l'Appareil Digestiv, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"La Torre","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universit\u00e0 degli Studi di Roma \u2018Sapienza\u2019, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C G M I","family":"Baeten","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The 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