{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:50:53Z","timestamp":1785876653881,"version":"3.56.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":1132,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The optimal extent of groin completion lymph node dissection (CLND) (inguinal or ilioinguinal dissection) in patients with melanoma is controversial. The aim of this study was to evaluate whether the extent of groin CLND after a positive sentinel node biopsy (SNB) is associated with improved outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from all sentinel node-positive patients who underwent groin CLND at four tertiary melanoma referral centres were retrieved retrospectively. Baseline patient and tumour characteristics were collected for descriptive statistics, survival analyses and Cox proportional hazards regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 255 patients were included, of whom 137 (53\u00b77 per cent) underwent inguinal dissection and 118 (46\u00b73 per cent) ilioinguinal dissection. The overall CLND positivity rate was 18\u00b78 per cent; the inguinal positivity rate was 15\u00b75 per cent and the pelvic positivity rate was 9\u00b73 per cent. The pattern of recurrence, and 5-year melanoma-specific survival, disease-free survival and distant-metastasis free survival rates were similar for both dissection types, even for patients with a positive CLND result. Cox regression analysis showed that type of CLND was not associated with disease-free or melanoma-specific survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There was no significant difference in recurrence pattern and survival rates between patients undergoing inguinal or ilioinguinal dissection after a positive SNB, even after stratification for a positive CLND result. An inguinal dissection is a safe first approach as CLND in patients with a positive SNB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10644","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T15:51:21Z","timestamp":1509637881000},"page":"96-105","source":"Crossref","is-referenced-by-count":14,"title":["Optimal extent of completion lymphadenectomy for patients with melanoma and a positive sentinel node in the groin"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0034-3575","authenticated-orcid":false,"given":"D","family":"Verver","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Madu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-1240","authenticated-orcid":false,"given":"C M C","family":"Oude Ophuis","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Faut","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Centre Groningen, Groningen University , Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H W","family":"de Wilt","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Radboud University Medical Centre , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Bonenkamp","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Radboud University Medical Centre , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Gr\u00fcnhagen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C J","family":"van Akkooi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B L","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Centre Groningen, Groningen University , Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2024092914120332200_bjs10644-bib-0001","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejca.2016.05.005","article-title":"European Dermatology Forum; European Association of Dermato-Oncology; European Organisation for Research and Treatment of Cancer. 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