{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:29:06Z","timestamp":1789964946551,"version":"4.0.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The subspecialization of colorectal surgeons, and improvements in the quality of mesorectal excision have revolutionized rectal cancer surgery. With the increasing use of minimally invasive techniques, the completeness of the mesorectal excision has been questioned. This study aimed to assess the pathological outcomes of open versus laparoscopic rectal resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A meta-analysis of RCTs was undertaken. The primary endpoint was the adequacy of the mesorectal excision. Secondary endpoints included circumferential resection margin and distance to resection margins.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Four studies were included, reporting on 2319 patients; 972 (41\u00b79 per cent) had open and 1347 (58\u00b71 per cent) had laparoscopic resections. Meta-analysis of adequacy of the mesorectal excision showed a small difference in achieving an intact mesorectum in favour of open surgery (risk ratio (RR) 1\u00b706, 95 per cent c.i. 1\u00b702 to 1\u00b710; P = 0\u00b7001). Superficial defects were more common in laparoscopic surgery (RR 0\u00b770, 0\u00b754 to 0\u00b789; P = 0\u00b7004). Deep mesorectal defects (RR 0\u00b778, 0\u00b751 to 1\u00b720; P = 0\u00b7256), circumferential margin (CRM) positivity (RR 0\u00b785, 0\u00b762 to 1\u00b716; P = 0\u00b7310), and distance to radial (mean difference (MD) \u20130\u00b706, 95 per cent c.i. \u20130\u00b710 to 0\u00b723; P = 0\u00b7443) and distal (MD 0\u00b703, \u20130\u00b706 to 0\u00b712; P = 0\u00b7497) margins were all similar. A complete resection (intact mesorectum, negative CRM and distal margin) was achieved in 350 of 478 patients (73\u00b72 per cent) in the laparoscopic group and 372 of 457 (81\u00b74 per cent) in the open group (risk difference (RD) 8 (95 per cent c.i. 3 to 13) per cent; P = 0\u00b7003). However, an acceptable mesorectum (intact or superficial defects only) was present in 1254 of 1308 (95\u00b79 per cent) and 916 of 949 (96\u00b75 per cent) in the laparoscopic and open groups respectively (RD 1 (\u20131 to 3) per cent; P = 0\u00b7263).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Small differences in mesorectal quality were evident between open and laparoscopic rectal resections. This may be attributable to use of laparoscopic instruments; however, to date minor defects have not affected oncological outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10664","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T08:20:21Z","timestamp":1508228421000},"page":"1609-1619","source":"Crossref","is-referenced-by-count":44,"title":["Meta-analysis of the impact of surgical approach on the grade of mesorectal excision in rectal cancer"],"prefix":"10.1093","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8209-4810","authenticated-orcid":false,"given":"B","family":"Creavin","sequence":"first","affiliation":[{"name":"Centre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-6411","authenticated-orcid":false,"given":"M E","family":"Kelly","sequence":"additional","affiliation":[{"name":"Centre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-0836","authenticated-orcid":false,"given":"E","family":"Ryan","sequence":"additional","affiliation":[{"name":"Centre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Winter","sequence":"additional","affiliation":[{"name":"Centre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"2021020617254749900_bjs10664-bib-0001","article-title":"Workload and surgeon's specialty for outcome after colorectal cancer surgery","volume-title":"Cochrane Database Syst Rev","author":"Archampong","year":"2012"},{"key":"2021020617254749900_bjs10664-bib-0002","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0140-6736(00)02469-7","article-title":"Effect of a surgical training programme on outcome of rectal cancer in the County of Stockholm. 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