{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:45:31Z","timestamp":1785548731109,"version":"3.56.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Ministry of Health","award":["AOM 11060"],"award-info":[{"award-number":["AOM 11060"]}]},{"name":"Association de Chirurgie H\u00e9pato-Biliaire et de Transplantation H\u00e9patique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The operative risk of hepatectomy under antiplatelet therapy is unknown. This study sought to assess the outcomes of elective hepatectomy performed with or without aspirin continuation in a well balanced matched cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were retrieved from a multicentre prospective observational study. Aspirin and control groups were compared by non-standardized methods and by propensity score (PS) matching analysis. The main outcome was severe (Dindo\u2013Clavien grade IIIa or more) haemorrhage. Other outcomes analysed were intraoperative transfusion, overall haemorrhage, major morbidity, comprehensive complication index (CCI) score, thromboembolic complications, ischaemic complications and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Before matching, there were 118 patients in the aspirin group and 1685 in the control group. ASA fitness grade, cardiovascular disease, previous history of angina pectoris, angioplasty, diabetes, use of vitamin K antagonists, cirrhosis and type of hepatectomy were significantly different between the groups. After PS matching, 108 patients were included in each group. There were no statistically significant differences between the aspirin and control groups in severe haemorrhage (6\u00b75 versus 5\u00b76 per cent respectively; odds ratio (OR) 1\u00b718, 95 per cent c.i. 0\u00b738 to 3\u00b762), intraoperative transfusion (23\u00b74 versus 23\u00b77 per cent; OR 0\u00b798, 0\u00b751 to 1\u00b787), overall haemorrhage (10\u00b72 versus 12\u00b70 per cent; OR 0\u00b783, 0\u00b735 to 1\u00b794), CCI score (24 versus 28; P = 0\u00b7520), major complications (23\u00b71 versus 13\u00b79 per cent; OR 1\u00b782, 0\u00b792 to 3\u00b779) and 90-day mortality (5\u00b76 versus 4\u00b76 per cent; OR 1\u00b721, 0\u00b736 to 4\u00b709).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This observational study suggested that aspirin continuation is not associated with a higher rate of bleeding-related complications after elective hepatic surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10697","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T15:22:43Z","timestamp":1518016963000},"page":"429-438","source":"Crossref","is-referenced-by-count":11,"title":["Use of aspirin and bleeding-related complications after hepatic resection"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-4021","authenticated-orcid":false,"given":"M.","family":"Gelli","sequence":"first","affiliation":[{"name":"Centre H\u00e9pato-Biliaire, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP-HP) H\u00f4pital Paul-Brousse, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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