{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:24:08Z","timestamp":1789788248446,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006364","name":"French National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database. Patients with EA-PMP had pathologically confirmed non-neoplastic appendices and were matched in a 1 : 4 ratio with patients treated for appendicular PMP (A-PMP), based on a propensity score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Some 726 patients were identified, of which 61 (EA-PMP group) were matched with 244 patients (A-PMP group). The origins of primary tumours in the EA-PMP group included the ovary (45 patients), colon (4), urachus (4), small bowel (1), pancreas (1) and unknown (6). The median peritoneal carcinomatosis index was comparable in EA-PMP and A-PMP groups (15\u00b75 versus 18 respectively; P = 0\u00b7315). In-hospital mortality (3 versus 2\u00b79 per\u00a0cent; P = 1\u00b7000) and major morbidity 26 versus 25\u00b70 per\u00a0cent; P = 0\u00b7869) were also similar between the two groups. Median follow-up was 66\u00b79 months. The 5-year overall survival rate was 87\u00b78 (95 per\u00a0cent c.i. 83\u00b72 to 92\u00b75) per\u00a0cent in the A-PMP group and 87 (77 to 96) per\u00a0cent in the EA-PMP group. The 5-year disease-free survival rate was 66\u00b70 (58\u00b77 to 73\u00b74) per cent and 70 (53 to 83) per cent respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall and disease-free survival following treatment with CCRS and HIPEC is similar in patients with pseudomyxoma peritonei of appendicular or extra-appendicular origin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.10716","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T16:12:38Z","timestamp":1518019958000},"page":"668-676","source":"Crossref","is-referenced-by-count":47,"title":["Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-3123","authenticated-orcid":false,"given":"J-B","family":"Delhorme","sequence":"first","affiliation":[{"name":"Department of General and 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