{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:38:26Z","timestamp":1783633106221,"version":"3.55.0"},"reference-count":119,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Germline mutations are present in 20\u201330 per cent of patients with phaeochromocytoma. For patients who develop bilateral disease, complete removal of both adrenal glands (total adrenalectomy) will result in lifelong adrenal insufficiency with an increased risk of death from adrenal crisis. Unilateral\/bilateral adrenal-sparing surgery (subtotal adrenalectomy) offers preservation of cortical function and independence from steroids, but leaves the adrenal medulla in situ and thus at risk of developing new and possibly malignant disease. Here, present knowledge about how tumour genotype relates to clinical behaviour is reviewed, and application of this knowledge when choosing the extent of adrenalectomy is discussed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A literature review was undertaken of the penetrance of the different genotypes in phaeochromocytomas, the frequency of bilateral disease and malignancy, and the underlying pathophysiological mechanisms, with emphasis on explaining the clinical phenotypes of phaeochromocytomas and their associated syndromes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with bilateral phaeochromocytomas most often have multiple endocrine neoplasia type 2 (MEN2) or von Hippel\u2013Lindau disease (VHL) with high-penetrance mutations for benign disease, whereas patients with mutations in the genes encoding SDHB (succinate dehydrogenase subunit B) or MAX (myelocytomatosis viral proto-oncogene homologue-associated factor X) are at increased risk of malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adrenal-sparing surgery should be the standard approach for patients who have already been diagnosed with MEN2 or VHL when operating on the first side, whereas complete removal of the affected adrenal gland(s) is generally recommended for patients with SDHB or MAX germline mutations. Routine assessment of a patient's genotype, even after the first operation, can be crucial for adopting an appropriate strategy for follow-up and future surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10744","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T11:43:20Z","timestamp":1516189400000},"page":"e84-e98","source":"Crossref","is-referenced-by-count":38,"title":["Extent of surgery for phaeochromocytomas in the genomic era"],"prefix":"10.1093","volume":"105","author":[{"given":"H M","family":"Rossitti","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"S\u00f6derkvist","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0054-664X","authenticated-orcid":false,"given":"O","family":"Gimm","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"Department of Surgery, County Council of \u00d6sterg\u00f6tland, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"2021020617165731400_bjs10744-bib-0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086756","article-title":"Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours","volume":"9","author":"Crona","year":"2014","journal-title":"PLoS One"},{"key":"2021020617165731400_bjs10744-bib-0002","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ccell.2017.01.001","article-title":"Comprehensive molecular characterization of pheochromocytoma and paraganglioma","volume":"31","author":"Fishbein","year":"2017","journal-title":"Cancer Cell"},{"key":"2021020617165731400_bjs10744-bib-0003","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1210\/jc.2008-2419","article-title":"Clinically guided genetic screening in a large cohort of Italian patients with pheochromocytomas and\/or functional or nonfunctional paragangliomas","volume":"94","author":"Mannelli","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0004","doi-asserted-by":"crossref","first-page":"R253","DOI":"10.1530\/ERC-11-0170","article-title":"Genetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas","volume":"18","author":"Welander","year":"2011","journal-title":"Endocr Relat Cancer"},{"key":"2021020617165731400_bjs10744-bib-0005","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/jnnp-2012-303028","article-title":"Neurological manifestations of phaeochromocytomas and secretory paragangliomas: a reappraisal","volume":"84","author":"Anderson","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2021020617165731400_bjs10744-bib-0006","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1097\/HJH.0b013e32834a4ce9","article-title":"Cardiovascular manifestations of phaeochromocytoma","volume":"29","author":"Prejbisz","year":"2011","journal-title":"J Hypertens"},{"key":"2021020617165731400_bjs10744-bib-0007","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00423-011-0880-x","article-title":"Malignant pheochromocytomas and paragangliomas: a diagnostic challenge","volume":"397","author":"Gimm","year":"2012","journal-title":"Langenbecks Arch Surg"},{"key":"2021020617165731400_bjs10744-bib-0008","doi-asserted-by":"crossref","first-page":"T123","DOI":"10.1530\/ERC-15-0261","article-title":"15 years of paraganglioma: pathology of pheochromocytoma and paraganglioma","volume":"22","author":"Tischler","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"2021020617165731400_bjs10744-bib-0009","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/onc.2015.172","article-title":"Rethinking pheochromocytomas and paragangliomas from a genomic perspective","volume":"35","author":"Castro-Vega","year":"2016","journal-title":"Oncogene"},{"key":"2021020617165731400_bjs10744-bib-0010","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1080\/11024159950189320","article-title":"Complications after bilateral adrenalectomy for phaeochromocytoma in multiple endocrine neoplasia type 2 \u2013 a plea to conserve adrenal function","volume":"165","author":"de Graaf","year":"1999","journal-title":"Eur J Surg"},{"key":"2021020617165731400_bjs10744-bib-0011","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/cen.12603","article-title":"Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy","volume":"82","author":"Johannsson","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021020617165731400_bjs10744-bib-0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beem.2014.09.009","article-title":"Optimal glucocorticoid replacement in adrenal insufficiency","volume":"29","author":"\u00d8ksnes","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0013","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1530\/EJE-15-0549","article-title":"Management of endocrine disease: outcome of adrenal sparing surgery in heritable pheochromocytoma","volume":"174","author":"Castinetti","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"2021020617165731400_bjs10744-bib-0014","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0022-5347(01)62886-6","article-title":"Laparoscopic surgery for pheochromocytoma: adrenalectomy, partial resection, excision of paragangliomas","volume":"160","author":"Janetschek","year":"1998","journal-title":"J Urol"},{"key":"2021020617165731400_bjs10744-bib-0015","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S1470-2045(14)70154-8","article-title":"Outcomes of adrenal-sparing surgery or total adrenalectomy in phaeochromocytoma associated with multiple endocrine neoplasia type 2: an international retrospective population-based study","volume":"15","author":"Castinetti","year":"2014","journal-title":"Lancet Oncol"},{"key":"2021020617165731400_bjs10744-bib-0016","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jamcollsurg.2012.10.012","article-title":"Long-term outcomes of surgical treatment for hereditary pheochromocytoma","volume":"216","author":"Grubbs","year":"2013","journal-title":"J Am Coll Surg"},{"key":"2021020617165731400_bjs10744-bib-0017","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00423-011-0851-2","article-title":"Minimally invasive cortical-sparing surgery for bilateral pheochromocytomas","volume":"397","author":"Alesina","year":"2012","journal-title":"Langenbecks Arch Surg"},{"key":"2021020617165731400_bjs10744-bib-0018","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.surg.2003.08.005","article-title":"Critical size of residual adrenal tissue and recovery from impaired early postoperative adrenocortical function after subtotal bilateral adrenalectomy","volume":"134","author":"Brauckhoff","year":"2003","journal-title":"Surgery"},{"key":"2021020617165731400_bjs10744-bib-0019","doi-asserted-by":"crossref","first-page":"T135","DOI":"10.1530\/ERC-15-0175","article-title":"15 years of paraganglioma: imaging and imaging-based treatment of pheochromocytoma and paraganglioma","volume":"22","author":"Castinetti","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"2021020617165731400_bjs10744-bib-0020","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an Endocrine Society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0021","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12022-006-0003-3","article-title":"Molecular and cellular biology of pheochromocytomas and extra-adrenal paragangliomas","volume":"17","author":"Tischler","year":"2006","journal-title":"Endocr Pathol"},{"key":"2021020617165731400_bjs10744-bib-0022","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1210\/me.2010-0256","article-title":"Research resource: transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas","volume":"24","author":"L\u00f3pez-Jim\u00e9nez","year":"2010","journal-title":"Mol Endocrinol"},{"key":"2021020617165731400_bjs10744-bib-0023","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0002-9440(10)64400-8","article-title":"Angiogenesis and vascular architecture in pheochromocytomas: distinctive traits in malignant tumors","volume":"161","author":"Favier","year":"2002","journal-title":"Am J Pathol"},{"key":"2021020617165731400_bjs10744-bib-0024","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1002\/ijc.28868","article-title":"Opposing effects of HIF1alpha and HIF2alpha on chromaffin cell phenotypic features and tumor cell proliferation: insights from MYC-associated factor X","volume":"135","author":"Qin","year":"2014","journal-title":"Int J Cancer"},{"key":"2021020617165731400_bjs10744-bib-0025","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1158\/1078-0432.CCR-16-0606","article-title":"Pheochromocytoma: the first metabolic endocrine cancer","volume":"22","author":"Jochmanova","year":"2016","journal-title":"Clin Cancer Res"},{"key":"2021020617165731400_bjs10744-bib-0026","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5603\/EP.2016.0008","article-title":"Occurrence of phaeochromocytoma tumours in RET mutation carriers \u2013 a single-centre study","volume":"67","author":"Kotecka-Blicharz","year":"2016","journal-title":"Endokrynol Pol"},{"key":"2021020617165731400_bjs10744-bib-0027","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1210\/jc.2005-0064","article-title":"Codon-specific development of pheochromocytoma in multiple endocrine neoplasia type 2","volume":"90","author":"Machens","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0028","doi-asserted-by":"crossref","first-page":"E1813","DOI":"10.1210\/jc.2013-1653","article-title":"The characterization of pheochromocytoma and its impact on overall survival in multiple endocrine neoplasia type 2","volume":"98","author":"Thosani","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0029","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2016-3829","article-title":"Characteristics of pediatric vs adult pheochromocytomas and paragangliomas","volume":"102","author":"Pamporaki","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0030","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/neuonc\/nov313","article-title":"Von Hippel\u2013Lindau disease: an evaluation of natural history and functional disability","volume":"18","author":"Feletti","year":"2016","journal-title":"Neuro Oncol"},{"key":"2021020617165731400_bjs10744-bib-0031","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1210\/jc.2015-3045","article-title":"Trebska-McGowan K, Nilubol N et al. Pheochromocytoma screening initiation and frequency in von Hippel\u2013Lindau syndrome","volume":"100","author":"Aufforth","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0032","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/humu.20385","article-title":"Genotype\u2013phenotype correlations in von Hippel\u2013Lindau disease","volume":"28","author":"Ong","year":"2007","journal-title":"Hum Mutat"},{"key":"2021020617165731400_bjs10744-bib-0033","doi-asserted-by":"crossref","first-page":"38456","DOI":"10.18632\/oncotarget.16594","article-title":"Genotype\u2013phenotype correlations in Chinese von Hippel\u2013Lindau disease patients","volume":"8","author":"Peng","year":"2017","journal-title":"Oncotarget"},{"issue":"3 Pt 1","key":"2021020617165731400_bjs10744-bib-0034","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00005392-199909010-00004","article-title":"Clinical and genetic characterization of pheochromocytoma in von Hippel\u2013Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma","volume":"162","author":"Walther","year":"1999","journal-title":"J Urol"},{"key":"2021020617165731400_bjs10744-bib-0035","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.surg.2016.05.050","article-title":"SDHB mutation status and tumor size but not tumor grade are important predictors of clinical outcome in pheochromocytoma and abdominal paraganglioma","volume":"161","author":"Assadipour","year":"2017","journal-title":"Surgery"},{"key":"2021020617165731400_bjs10744-bib-0036","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2005-1862","article-title":"Clinical presentation and penetrance of pheochromocytoma\/paraganglioma syndromes","volume":"91","author":"Benn","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0037","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00432-017-2397-3","article-title":"SDHB-related pheochromocytoma and paraganglioma penetrance and genotype\u2013phenotype correlations","volume":"143","author":"Jochmanova","year":"2017","journal-title":"J Cancer Res Clin Oncol"},{"key":"2021020617165731400_bjs10744-bib-0038","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/cen.13246","article-title":"Outcomes of annual surveillance imaging in an adult and paediatric cohort of succinate dehydrogenase B mutation carriers","volume":"86","author":"Tufton","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021020617165731400_bjs10744-bib-0039","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10689-014-9738-z","article-title":"Phenotype of SDHB mutation carriers in the Netherlands","volume":"13","author":"van Hulsteijn","year":"2014","journal-title":"Fam Cancer"},{"key":"2021020617165731400_bjs10744-bib-0040","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/jama.292.8.943","article-title":"Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations","volume":"292","author":"Neumann","year":"2004","journal-title":"JAMA"},{"key":"2021020617165731400_bjs10744-bib-0041","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1001\/jamaoncol.2017.0223","article-title":"Clinical characterization of the pheochromocytoma and paraganglioma susceptibility genes SDHA, TMEM127, MAX, and SDHAF2 for gene-informed prevention","volume":"3","author":"Bausch","year":"2017","journal-title":"JAMA Oncol"},{"key":"2021020617165731400_bjs10744-bib-0042","doi-asserted-by":"crossref","first-page":"E1392","DOI":"10.1210\/jc.2013-4536","article-title":"Universal genetic screening uncovers a novel presentation of an SDHAF2 mutation","volume":"99","author":"Casey","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0043","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00403-010-1090-z","article-title":"Neurofibromatosis type 1 (NF1) and pheochromocytoma: prevalence, clinical and cardiovascular aspects","volume":"303","author":"Zinnamosca","year":"2011","journal-title":"Arch Dermatol Res"},{"key":"2021020617165731400_bjs10744-bib-0044","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/cen.13265","article-title":"Pheochromocytomas are diagnosed incidentally and at older age in neurofibromatosis type 1","volume":"86","author":"Moramarco","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021020617165731400_bjs10744-bib-0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/cen.13163","article-title":"Pheochromocytoma and paraganglioma in patients with neurofibromatosis type 1","volume":"86","author":"Gruber","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021020617165731400_bjs10744-bib-0046","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1530\/EJE-16-0233","article-title":"Interest of systematic screening of pheochromocytoma in patients with neurofibromatosis type 1","volume":"175","author":"K\u00e9p\u00e9n\u00e9kian","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"2021020617165731400_bjs10744-bib-0047","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1210\/jc.2006-2833","article-title":"Germline NF1 mutational spectra and loss-of-heterozygosity analyses in patients with pheochromocytoma and neurofibromatosis type 1","volume":"92","author":"Bausch","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0048","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1530\/ERC-13-0384","article-title":"Frequent EPAS1\/HIF2alpha exons 9 and 12 mutations in non-familial pheochromocytoma","volume":"21","author":"Welander","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"2021020617165731400_bjs10744-bib-0049","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1093\/hmg\/ddt639","article-title":"Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas","volume":"23","author":"Castro-Vega","year":"2014","journal-title":"Hum Mol Genet"},{"key":"2021020617165731400_bjs10744-bib-0050","doi-asserted-by":"crossref","first-page":"E1352","DOI":"10.1210\/jc.2013-4375","article-title":"Rare germline mutations identified by targeted next-generation sequencing of susceptibility genes in pheochromocytoma and paraganglioma","volume":"99","author":"Welander","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0051","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00439-008-0553-1","article-title":"A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors","volume":"124","author":"Yeh","year":"2008","journal-title":"Hum Genet"},{"key":"2021020617165731400_bjs10744-bib-0052","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1158\/1078-0432.CCR-12-0160","article-title":"MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma","volume":"18","author":"Burnichon","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2021020617165731400_bjs10744-bib-0053","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1001\/jama.2010.1830","article-title":"Spectrum and prevalence of FP\/TMEM127 gene mutations in pheochromocytomas and paragangliomas","volume":"304","author":"Yao","year":"2010","journal-title":"JAMA"},{"key":"2021020617165731400_bjs10744-bib-0054","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/gcc.22347","article-title":"HRAS mutation prevalence and associated expression patterns in pheochromocytoma","volume":"55","author":"Stenman","year":"2016","journal-title":"Genes Chromosomes Cancer"},{"key":"2021020617165731400_bjs10744-bib-0055","doi-asserted-by":"crossref","first-page":"E1376","DOI":"10.1210\/jc.2013-3879","article-title":"H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series","volume":"99","author":"Oudijk","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0056","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1093\/hmg\/dds402","article-title":"Integrative genomics reveals frequent somatic NF1 mutations in sporadic pheochromocytomas","volume":"21","author":"Welander","year":"2012","journal-title":"Hum Mol Genet"},{"key":"2021020617165731400_bjs10744-bib-0057","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1093\/hmg\/ddr324","article-title":"Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma","volume":"20","author":"Burnichon","year":"2011","journal-title":"Hum Mol Genet"},{"key":"2021020617165731400_bjs10744-bib-0058","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/jmedgenet-2015-103218","article-title":"Recommendations for somatic and germline genetic testing of single pheochromocytoma and paraganglioma based on findings from a series of 329 patients","volume":"52","author":"Curr\u00e1s-Freixes","year":"2015","journal-title":"J Med Genet"},{"key":"2021020617165731400_bjs10744-bib-0059","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/hmg\/ddt069","article-title":"Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis","volume":"22","author":"Comino-M\u00e9ndez","year":"2013","journal-title":"Hum Mol Genet"},{"key":"2021020617165731400_bjs10744-bib-0060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.6061\/clinics\/2012(Sup01)13","article-title":"Genotype\u2013phenotype correlation in multiple endocrine neoplasia type 2","volume":"67","author":"Raue","year":"2012","journal-title":"Clinics (Sao Paulo)"},{"key":"2021020617165731400_bjs10744-bib-0061","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1007\/s00268-008-9734-2","article-title":"Pheochromocytoma in MEN 2A syndrome. Study of 54 patients","volume":"32","author":"Rodriguez","year":"2008","journal-title":"World J Surg"},{"key":"2021020617165731400_bjs10744-bib-0062","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00268-004-7637-4","article-title":"Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: clinical manifestation and course in early and late onset disease","volume":"28","author":"Brauckhoff","year":"2004","journal-title":"World J Surg"},{"key":"2021020617165731400_bjs10744-bib-0063","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/humu.21385","article-title":"Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10","volume":"32","author":"Frank-Raue","year":"2011","journal-title":"Hum Mutat"},{"key":"2021020617165731400_bjs10744-bib-0064","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.surg.2007.09.013","article-title":"Pheochromocytoma penetrance varies by RET mutation in MEN 2A","volume":"142","author":"Quayle","year":"2007","journal-title":"Surgery"},{"key":"2021020617165731400_bjs10744-bib-0065","first-page":"16","article-title":"Disease-modifying polymorphisms and C609Y mutation of RET associated with high penetrance of phaeochromocytoma and low rate of MTC in MEN2A","volume":"2016","author":"Speak","year":"2016","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"2021020617165731400_bjs10744-bib-0066","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1007\/s00268-015-3117-2","article-title":"Bilateral pheochromocytomas in MEN2A syndrome: a two-institution experience","volume":"39","author":"Lang","year":"2015","journal-title":"World J Surg"},{"key":"2021020617165731400_bjs10744-bib-0067","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/EJE-14-0818","article-title":"RET Cys634Arg mutation confers a more aggressive multiple endocrine neoplasia type 2A phenotype than Cys634Tyr mutation","volume":"172","author":"Vald\u00e9s","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"2021020617165731400_bjs10744-bib-0068","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.neo.2014.09.002","article-title":"Adrenal medullary hyperplasia is a precursor lesion for pheochromocytoma in MEN2 syndrome","volume":"16","author":"Korpershoek","year":"2014","journal-title":"Neoplasia"},{"key":"2021020617165731400_bjs10744-bib-0069","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s005950300078","article-title":"Functional results after endoscopic subtotal cortical-sparing adrenalectomy","volume":"33","author":"Brauckhoff","year":"2003","journal-title":"Surg Today"},{"key":"2021020617165731400_bjs10744-bib-0070","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/hmg\/10.10.1019","article-title":"von Hippel\u2013Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF","volume":"10","author":"Hoffman","year":"2001","journal-title":"Hum Mol Genet"},{"key":"2021020617165731400_bjs10744-bib-0071","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1158\/0008-5472.CAN-05-2560","article-title":"Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis","volume":"66","author":"Kurban","year":"2006","journal-title":"Cancer Res"},{"key":"2021020617165731400_bjs10744-bib-0072","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ccr.2005.06.015","article-title":"Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer","volume":"8","author":"Lee","year":"2005","journal-title":"Cancer Cell"},{"key":"2021020617165731400_bjs10744-bib-0073","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/hmg\/10.10.1029","article-title":"Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel\u2013Lindau disease","volume":"10","author":"Clifford","year":"2001","journal-title":"Hum Mol Genet"},{"key":"2021020617165731400_bjs10744-bib-0074","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.juro.2010.06.102","article-title":"Functional and oncologic outcomes of partial adrenalectomy for pheochromocytoma in patients with von Hippel\u2013Lindau syndrome after at least 5 years of followup","volume":"184","author":"Benhammou","year":"2010","journal-title":"J Urol"},{"key":"2021020617165731400_bjs10744-bib-0075","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.jpedsurg.2012.07.003","article-title":"Partial adrenalectomy minimizes the need for long-term hormone replacement in pediatric patients with pheochromocytoma and von Hippel\u2013Lindau syndrome","volume":"47","author":"Volkin","year":"2012","journal-title":"J Pediatr Surg"},{"key":"2021020617165731400_bjs10744-bib-0076","doi-asserted-by":"crossref","first-page":"T91","DOI":"10.1530\/ERC-15-0268","article-title":"15 years of paraganglioma: clinical manifestations of paraganglioma syndromes types 1\u20135","volume":"22","author":"Benn","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"2021020617165731400_bjs10744-bib-0077","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1210\/jc.2007-0709","article-title":"Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas","volume":"92","author":"Amar","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0078","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.mito.2010.03.001","article-title":"Succinate dehydrogenase \u2013 assembly, regulation and role in human disease","volume":"10","author":"Rutter","year":"2010","journal-title":"Mitochondrion"},{"key":"2021020617165731400_bjs10744-bib-0079","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/humu.21136","article-title":"Tumor risks and genotype\u2013phenotype\u2013proteotype analysis in 358 patients with germline mutations in SDHB and SDHD","volume":"31","author":"Ricketts","year":"2010","journal-title":"Hum Mutat"},{"key":"2021020617165731400_bjs10744-bib-0080","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/jso.23297","article-title":"Malignant pheochromocytoma and paraganglioma: a population level analysis of long-term survival over two decades","volume":"107","author":"Goffredo","year":"2013","journal-title":"J Surg Oncol"},{"key":"2021020617165731400_bjs10744-bib-0081","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00423-011-0871-y","article-title":"Paraganglioma: not just an extra-adrenal pheochromocytoma","volume":"397","author":"Laird","year":"2012","journal-title":"Langenbecks Arch Surg"},{"key":"2021020617165731400_bjs10744-bib-0082","doi-asserted-by":"crossref","first-page":"E2009","DOI":"10.1210\/jc.2011-1244","article-title":"Molecular analysis of pheochromocytoma after maternal transmission of SDHD mutation elucidates mechanism of parent-of-origin effect","volume":"96","author":"Yeap","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0083","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1001\/jama.294.16.2057","article-title":"Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene","volume":"294","author":"Schiavi","year":"2005","journal-title":"JAMA"},{"key":"2021020617165731400_bjs10744-bib-0084","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ncpendmet0726","article-title":"Extra-adrenal and adrenal pheochromocytomas associated with a germline SDHC mutation","volume":"4","author":"Peczkowska","year":"2008","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13053-016-0053-6","article-title":"Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma\/paraganglioma patients","volume":"14","author":"Bennedbaek","year":"2016","journal-title":"Hered Cancer Clin Pract"},{"key":"2021020617165731400_bjs10744-bib-0086","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.surg.2011.09.024","article-title":"Is genetic screening indicated in apparently sporadic pheochromocytomas and paragangliomas?","volume":"150","author":"Iacobone","year":"2011","journal-title":"Surgery"},{"key":"2021020617165731400_bjs10744-bib-0087","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10689-015-9821-0","article-title":"Metastatic sympathetic paraganglioma in a patient with loss of the SDHC gene","volume":"14","author":"Rich","year":"2015","journal-title":"Fam Cancer"},{"key":"2021020617165731400_bjs10744-bib-0088","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/jmg.2007.051045","article-title":"Genetic screening for pheochromocytoma: should SDHC gene analysis be included?","volume":"44","author":"Mannelli","year":"2007","journal-title":"J Med Genet"},{"key":"2021020617165731400_bjs10744-bib-0089","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jamcollsurg.2013.04.027","article-title":"Response after surgical resection of metastatic pheochromocytoma and paraganglioma: can postoperative biochemical remission be predicted?","volume":"217","author":"Ellis","year":"2013","journal-title":"J Am Coll Surg"},{"key":"2021020617165731400_bjs10744-bib-0090","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/modpathol.2015.41","article-title":"SDHB\/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)","volume":"28","author":"Papathomas","year":"2015","journal-title":"Mod Pathol"},{"key":"2021020617165731400_bjs10744-bib-0091","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S1470-2045(09)70164-0","article-title":"An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis","volume":"10","author":"van Nederveen","year":"2009","journal-title":"Lancet Oncol"},{"key":"2021020617165731400_bjs10744-bib-0092","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1210\/jc.2006-0920","article-title":"Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations","volume":"91","author":"Pollard","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0093","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1593\/neo.122132","article-title":"Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas","volume":"15","author":"Shankavaram","year":"2013","journal-title":"Neoplasia"},{"key":"2021020617165731400_bjs10744-bib-0094","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/hmg\/ddi227","article-title":"Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations","volume":"14","author":"Pollard","year":"2005","journal-title":"Hum Mol Genet"},{"key":"2021020617165731400_bjs10744-bib-0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-0-444-62702-5.00004-4","article-title":"Neurofibromatosis type 1","volume":"132","author":"Anderson","year":"2015","journal-title":"Handb Clin Neurol"},{"key":"2021020617165731400_bjs10744-bib-0096","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/mgg3.161","article-title":"126 novel mutations in Italian patients with neurofibromatosis type 1","volume":"3","author":"Bianchessi","year":"2015","journal-title":"Mol Genet Genomic Med"},{"key":"2021020617165731400_bjs10744-bib-0097","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0022-5347(05)68171-2","article-title":"Recklinghausen's disease and pheochromocytomas","volume":"162","author":"Walther","year":"1999","journal-title":"J Urol"},{"key":"2021020617165731400_bjs10744-bib-0098","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1530\/ERC-13-0101","article-title":"In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas","volume":"20","author":"Toledo","year":"2013","journal-title":"Endocr Relat Cancer"},{"key":"2021020617165731400_bjs10744-bib-0099","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1101\/gad.1648608","article-title":"The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor","volume":"22","author":"Schlisio","year":"2008","journal-title":"Genes Dev"},{"key":"2021020617165731400_bjs10744-bib-0100","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ng.861","article-title":"Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma","volume":"43","author":"Comino-M\u00e9ndez","year":"2011","journal-title":"Nat Genet"},{"key":"2021020617165731400_bjs10744-bib-0101","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1128\/MCB.15.7.3470","article-title":"The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max","volume":"15","author":"Hopewell","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2021020617165731400_bjs10744-bib-0102","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbagrm.2014.05.016","article-title":"Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis","volume":"1849","author":"Diolaiti","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2021020617165731400_bjs10744-bib-0103","volume-title":"Endocr Pathol","author":"Romanet","year":"2016"},{"key":"2021020617165731400_bjs10744-bib-0104","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1038\/ncomms7140","article-title":"Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas","volume":"6","author":"Fishbein","year":"2015","journal-title":"Nat Commun"},{"key":"2021020617165731400_bjs10744-bib-0105","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"2021020617165731400_bjs10744-bib-0106","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrendo.2016.185","article-title":"Consensus Statement on next-generation-sequencing-based diagnostic testing of hereditary phaeochromocytomas and paragangliomas","volume":"13","author":"NGS in PPGL (NGSnPPGL) Study Group","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"2021020617165731400_bjs10744-bib-0107","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00268-012-1430-6","article-title":"Prevalence of germline mutations in patients with pheochromocytoma or abdominal paraganglioma and sporadic presentation: a population-based study in Western Sweden","volume":"36","author":"Muth","year":"2012","journal-title":"World J Surg"},{"key":"2021020617165731400_bjs10744-bib-0108","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/EJE-08-0574","article-title":"Should genetic testing be performed in each patient with sporadic pheochromocytoma at presentation?","volume":"160","author":"Pigny","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"2021020617165731400_bjs10744-bib-0109","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1677\/ERC-06-0044","article-title":"Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma","volume":"14","author":"Korpershoek","year":"2007","journal-title":"Endocr Relat Cancer"},{"key":"2021020617165731400_bjs10744-bib-0110","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1373\/clinchem.2010.153320","article-title":"Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma","volume":"57","author":"Eisenhofer","year":"2011","journal-title":"Clin Chem"},{"key":"2021020617165731400_bjs10744-bib-0111","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1210\/jc.2014-3863","article-title":"Pheochromocytoma and paraganglioma in cyanotic congenital heart disease","volume":"100","author":"Opotowsky","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2021020617165731400_bjs10744-bib-0112","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00268-002-6632-x","article-title":"Endoscopic treatment of solitary, bilateral, multiple, and recurrent pheochromocytomas and paragangliomas","volume":"26","author":"Walz","year":"2002","journal-title":"World J Surg"},{"key":"2021020617165731400_bjs10744-bib-0113","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.surg.2003.07.027","article-title":"Adrenal-preserving laparoscopic surgery in selected patients with bilateral adrenal tumors","volume":"134","author":"Iihara","year":"2003","journal-title":"Surgery"},{"key":"2021020617165731400_bjs10744-bib-0114","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s13304-011-0052-0","article-title":"Laparoscopic adrenal-sparing surgery: personal experience, review on technical aspects","volume":"63","author":"Cavallaro","year":"2011","journal-title":"Updates Surg"},{"key":"2021020617165731400_bjs10744-bib-0115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/089277902753716142","article-title":"Laparoscopic partial adrenalectomy for recurrent pheochromocytoma after open partial adrenalectomy in von Hippel\u2013Lindau disease","volume":"16","author":"Al-Sobhi","year":"2002","journal-title":"J Endourol"},{"key":"2021020617165731400_bjs10744-bib-0116","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00595-003-2690-4","article-title":"Repeat adrenocortical-sparing adrenalectomy for recurrent hereditary pheochromocytoma","volume":"34","author":"Brauckhoff","year":"2004","journal-title":"Surg Today"},{"key":"2021020617165731400_bjs10744-bib-0117","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00268-007-9402-y","article-title":"Limitations of intraoperative adrenal remnant volume measurement in patients undergoing subtotal adrenalectomy","volume":"32","author":"Brauckhoff","year":"2008","journal-title":"World J Surg"},{"key":"2021020617165731400_bjs10744-bib-0118","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1046\/j.1445-2197.2001.02219.x","article-title":"Adrenal-sparing adrenalectomy in hereditary bilateral phaeochromocytoma","volume":"71","author":"Takami","year":"2001","journal-title":"ANZ J Surg"},{"key":"2021020617165731400_bjs10744-bib-0119","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00268-005-0373-6","article-title":"Laparoscopic and retroperitoneoscopic treatment of pheochromocytomas and retroperitoneal paragangliomas: results of 161 tumors in 126 patients","volume":"30","author":"Walz","year":"2006","journal-title":"World J Surg"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.10744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/105\/2\/e84\/36206402\/bjs10744.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/105\/2\/e84\/36206402\/bjs10744.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T14:19:10Z","timestamp":1621520350000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/105\/2\/e84-e98\/6122988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":119,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,1,17]]},"published-print":{"date-parts":[[2018,1,17]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.10744","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1]]},"published":{"date-parts":[[2018,1]]}}}