{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:39:48Z","timestamp":1790433588047,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1063476"],"award-info":[{"award-number":["1063476"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1117061"],"award-info":[{"award-number":["1117061"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1000967"],"award-info":[{"award-number":["1000967"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Revascularization is being used increasingly for the treatment of intermittent claudication and yet few studies have reported the long-term outcomes of this strategy. The aim of this study was to compare the long-term outcome of patients with intermittent claudication who underwent revascularization compared with a group initially treated without revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with symptoms of intermittent claudication and a diagnosis of peripheral arterial disease were recruited from outpatient clinics at three hospitals in Queensland, Australia. Based on variation in the practices of different vascular specialists, patients were either treated by early revascularization or received initial conservative treatment. Patients were followed in outpatient clinics using linked hospital admission record data. The primary outcome was the requirement for major amputation. Kaplan\u2013Meier curves, Cox regression and competing risks analyses were used to compare major amputation rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Some 456 patients were recruited; 178 (39\u00b70 per cent) underwent early revascularization and 278 (61\u00b70 per cent) had initial conservative treatment. Patients were followed for a mean(s.d.) of 5\u00b700(3\u00b737) years. The estimated 5-year major amputation rate was 6\u00b72 and 0\u00b77 per cent in patients undergoing early revascularization and initial conservative treatment respectively (P = 0\u00b7003). Early revascularization was associated with an increased requirement for major amputation in models adjusted for other risk factors (relative risk 5\u00b740 to 4\u00b722 in different models).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients presenting with intermittent claudication who underwent early revascularization appeared to be at higher risk of amputation than those who had initial conservative treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.10765","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T17:33:48Z","timestamp":1521740028000},"page":"699-708","source":"Crossref","is-referenced-by-count":67,"title":["Risk of major amputation in patients with intermittent claudication undergoing early revascularization"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-8848","authenticated-orcid":false,"given":"J","family":"Golledge","sequence":"first","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia"},{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia"},{"name":"Department of Vascular and Endovascular Surgery, Townsville Hospital, Townsville, Queensland, Australia"},{"name":"Department of Vascular and Endovascular Surgery, Mater Hospital, Townsville, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J V","family":"Moxon","sequence":"additional","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia"},{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rowbotham","sequence":"additional","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia"},{"name":"School of Medicine, University of Queensland, Brisbane, Queensland, Australia"},{"name":"Department of Vascular and Endovascular Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pinchbeck","sequence":"additional","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Yip","sequence":"additional","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Velu","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Townsville Hospital, Townsville, Queensland, Australia"},{"name":"Department of Vascular and Endovascular Surgery, Mater Hospital, Townsville, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Quigley","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Mater Hospital, Townsville, Queensland, 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