{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:46:49Z","timestamp":1790614009847,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"China Scholarship Council and the Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University","award":["XJTU1AF-CRF-2017-004"],"award-info":[{"award-number":["XJTU1AF-CRF-2017-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The role of routine lymph node dissection (LND) in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) remains controversial. The objective of this study was to investigate the trends of LND use in the surgical treatment of ICC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients undergoing curative intent resection for ICC in 2000\u20132015 were identified from an international multi-institutional database. Use of lymphadenectomy was evaluated over time and by geographical region (West versus East); LND use and final nodal status were analysed relative to AJCC T categories.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 1084 patients identified, half (535, 49\u00b74 per cent) underwent concomitant hepatic resection and LND. Between 2000 and 2015, the proportion of patients undergoing LND for ICC nearly doubled: 44\u00b74 per cent in 2000 versus 81\u00b75 per cent in 2015 (P &amp;lt; 0\u00b7001). Use of LND increased over time among both Eastern and Western centres. The odds of LND was associated with the time period of surgery and the extent of the tumour\/T status (referent T1a: OR 2\u00b743 for T2, P = 0\u00b7001; OR 2\u00b713 for T3, P = 0\u00b7016). Among the 535 patients who had LND, lymph node metastasis (LNM) was noted in 209 (39\u00b71 per cent). Specifically, the incidence of LNM was 24 per cent in T1a disease, 22 per cent in T1b, 42\u00b79 per cent in T2, 48 per cent in T3 and 66 per cent in T4 (P &amp;lt; 0\u00b7001). AJCC T3 and T4 categories, harvesting of six or more lymph nodes, and presence of satellite lesions were independently associated with LNM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The rate of LNM was high across all T categories, with one in five patients with T1 disease having nodal metastasis. The trend in increased use of LND suggests a growing adoption of AJCC recommendations in the treatment of ICC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10827","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T02:21:18Z","timestamp":1523758878000},"page":"857-866","source":"Crossref","is-referenced-by-count":90,"title":["Trends in use of lymphadenectomy in surgery with curative intent for intrahepatic cholangiocarcinoma"],"prefix":"10.1093","volume":"105","author":[{"given":"X -F","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"},{"name":"Department of Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, 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