{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:31:23Z","timestamp":1789655483096,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":1027,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005754","name":"Sahlgrenska University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2012-1770"],"award-info":[{"award-number":["2012-1770"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2015-02483"],"award-info":[{"award-number":["2015-02483"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"Health and Medical Care Committee of the Regional Executive Board and Region V\u00e4stra G\u00f6taland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014552","name":"Adlerbertska Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009735","name":"Alice Swenzons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010107","name":"Anna-Lisa and Bror Bj\u00f6rnsson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faith Regen Foundation"},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborg Medical Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005754","name":"Sahlgrenska University Hospital Health Technology Assessment Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009762","name":"Johan & Jacob S\u00f6derberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009792","name":"Bengt Ihre Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010349","name":"Wilhelm & Martina Lundgren Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvall Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009782","name":"Ruth and Richard Julin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009784","name":"Signe and Olof Wallenius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014197","name":"Mary von Sydow Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Traditionally, perforated diverticulitis with purulent peritonitis was treated with resection and colostomy (Hartmann's procedure), with inherent complications and risk of a permanent stoma. The DILALA (DIverticulitis \u2013 LAparoscopic LAvage versus resection (Hartmann's procedure) for acute diverticulitis with peritonitis) and other randomized trials found laparoscopic lavage to be a feasible and safe alternative. The medium-term follow-up results of DILALA are reported here.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients were randomized during surgery after being diagnosed with Hinchey grade III perforated diverticulitis at diagnostic laparoscopy. The primary outcome was the proportion of patients with one or more secondary operations from 0 to 24 months after the index procedure in the laparoscopic lavage versus Hartmann's procedure groups. The trial was registered as ISRCTN82208287.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-three patients were randomized to laparoscopic lavage and 40 to Hartmann's procedure. Patients in the lavage group had a 45 per cent reduced risk of undergoing one or more operations within 24 months (relative risk 0\u00b755, 95 per cent c.i. 0\u00b736 to 0\u00b784; P = 0\u00b7012) and had fewer operations (ratio 0\u00b751, 95 per cent c.i. 0\u00b731 to 0\u00b787; P = 0\u00b7024) compared with those in the Hartmann's group. No difference was found in mean number of readmissions (1\u00b737 versus 1\u00b750; P = 0\u00b7221) or mortality between patients randomized to laparoscopic lavage or Hartmann's procedure. Three patients in the lavage group and nine in the Hartmann's group had a colostomy at 24 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Laparoscopic lavage is a better option for perforated diverticulitis with purulent peritonitis than open resection and colostomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10839","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T03:53:50Z","timestamp":1523937230000},"page":"1128-1134","source":"Crossref","is-referenced-by-count":88,"title":["Two-year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis"],"prefix":"10.1093","volume":"105","author":[{"given":"A","family":"Kohl","sequence":"first","affiliation":[{"name":"Centre for Perioperative Optimization, Department of Surgery, Herlev Hospital, Herlev, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Centre for Perioperative Optimization, Department of Surgery, Herlev Hospital, Herlev, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital\/\u00d6stra, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bisgaard","sequence":"additional","affiliation":[{"name":"GastroUnit, Surgical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Skullman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sk\u00f6vde Hospital, Sk\u00f6vde, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Thornell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital\/\u00d6stra, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Gehrman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital\/\u00d6stra, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Angenete","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital\/\u00d6stra, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-5605","authenticated-orcid":false,"given":"E","family":"Haglind","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital\/\u00d6stra, Gothenburg, 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