{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:07:43Z","timestamp":1790863663748,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Surgical-site infection (SSI) is associated with significant healthcare costs. To reduce the high rate of SSI among patients undergoing colorectal surgery at a cancer centre, a comprehensive care bundle was implemented and its efficacy tested.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A pragmatic study involving three phases (baseline, implementation and sustainability) was conducted on patients treated consecutively between 2013 and 2016. The intervention included 13 components related to: bowel preparation; oral and intravenous antibiotic selection and administration; skin preparation, disinfection and hygiene; maintenance of normothermia during surgery; and use of clean instruments for closure. SSI risk was evaluated by means of a preoperative calculator, and effectiveness was assessed using interrupted time-series regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In a population with a mean BMI of 30 kg\/m2, diabetes mellitus in 17\u00b75 per cent, and smoking history in 49\u00b73 per cent, SSI rates declined from 11\u00b70 to 4\u00b71 per cent following implementation of the intervention bundle (P =\u00a00\u00b7001). The greatest reductions in SSI rates occurred in patients at intermediate or high risk of SSI: from 10\u00b73 to 4\u00b77 per cent (P = 0\u00b7006) and from 19 to 2 per cent (P &amp;lt; 0\u00b7001) respectively. Wound care modifications were very different in the implementation phase (43\u00b72 versus 24\u00b79 per cent baseline), including use of an overlying surface vacuum dressing (17\u00b72 from 1\u00b74 per cent baseline) or leaving wounds partially open (13\u00b72 from 6\u00b77 per cent baseline). As a result, the biggest difference was in wound-related rather than organ-space SSI. The median length of hospital stay decreased from 7 (i.q.r. 5\u201310) to 6 (5\u20139) days (P = 0\u00b7002). The greatest reduction in hospital stay was seen in patients at high risk of SSI: from 8 to 6 days (P &amp;lt; 0\u00b7001). SSI rates remained low (4\u00b75 per cent) in the sustainability phase.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Meaningful reductions in SSI can be achieved by implementing a multidisciplinary care bundle at a hospital-wide level.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10896","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T11:50:19Z","timestamp":1530705019000},"page":"1680-1687","source":"Crossref","is-referenced-by-count":76,"title":["Effectiveness of a multidisciplinary patient care bundle for reducing surgical-site infections"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9577-7984","authenticated-orcid":false,"given":"M R","family":"Weiser","sequence":"first","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 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