{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:09:42Z","timestamp":1790813382422,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Axillary lymph node status remains a significant prognostic indicator in breast cancer. Here, the diagnostic accuracy of ultrasound-guided fine-needle aspiration (US-FNA) and ultrasound-guided core needle biopsy (US-CNB) in axillary staging was compared.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A comprehensive search was undertaken of all published studies comparing the diagnostic accuracy of US-CNB and US-FNA of axillary lymph nodes in breast cancer. Studies were included if raw data were available on the diagnostic performance of both US-FNA and US-CNB, and compared with final histology results. Relevant data were extracted from each study for systematic review. Meta-analysis was performed using a random-effects model. The pooled sensitivity and specificity of US-FNA and US-CNB were obtained using a bivariable model. Summary receiver operating characteristic (ROC) graphs were created to confirm diagnostic accuracy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Data on a total of 1353 patients from six studies met the inclusion criteria and were included in the final analysis. US-CNB was superior to US-FNA in diagnosing axillary nodal metastases: sensitivity 88 (95 per cent c.i. 84 to 91) versus 74 (70 to 78) per cent respectively. Both US-CNB and US-FNA had a high specificity of 100 per cent. Reported complication rates were significantly higher for US-CNB compared with US-FNA (7\u00b71 versus 1\u00b73 per cent; P &lt; 0\u00b7001). Conversely, the requirement for repeat diagnostic procedures was significantly greater for US-FNA (4\u00b70 versus 0\u00b75 per cent; P &lt; 0\u00b7001).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n US-CNB is a superior diagnostic technique to US-FNA for axillary staging in breast cancer.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/bjs.10920","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T12:05:14Z","timestamp":1530705914000},"page":"1244-1253","source":"Crossref","is-referenced-by-count":95,"title":["Meta-analysis of the diagnostic accuracy of ultrasound-guided fine-needle aspiration and core needle biopsy in diagnosing axillary lymph node metastasis"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-5651","authenticated-orcid":false,"given":"I","family":"Balasubramanian","sequence":"first","affiliation":[{"name":"Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-2655","authenticated-orcid":false,"given":"C A","family":"Fleming","sequence":"additional","affiliation":[{"name":"Breast Cancer Research Centre, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Corrigan","sequence":"additional","affiliation":[{"name":"Breast Cancer Research Centre, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H P","family":"Redmond","sequence":"additional","affiliation":[{"name":"Breast Cancer Research Centre, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Kerin","sequence":"additional","affiliation":[{"name":"Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Lowery","sequence":"additional","affiliation":[{"name":"Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"2021020616554907100_bjs10920-bib-0001","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.diii.2015.07.007","article-title":"Diagnostic strategy for the assessment of axillary lymph node status in breast cancer","volume":"96","author":"Maxwell","year":"2015","journal-title":"Diagn Interv Imaging"},{"key":"2021020616554907100_bjs10920-bib-0002","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1148\/rg.347130141","article-title":"To do or not to do: axillary nodal evaluation after ACOSOG Z0011 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