{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:47:50Z","timestamp":1774478870986,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/256"],"award-info":[{"award-number":["12\/256"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008247","name":"University of Otago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dunedin School of Medicine Dean Bequest Fund","award":["2016"],"award-info":[{"award-number":["2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Proton pump inhibitors are the mainstay of treatment for gastro-oesophageal reflux disease, but are associated with ongoing costs and side-effects. Antireflux surgery is cost-effective and is preferred by many patients. A total (360o or Nissen) fundoplication is the traditional procedure, but other variations including partial fundoplications are also commonly performed, with the aim of achieving durable reflux control with minimal dysphagia. Many RCTs and some pairwise meta-analyses have compared some of these procedures but there is still uncertainty about which, if any, is superior. Network meta-analysis allows multiple simultaneous comparisons and robust synthesis of the available evidence in these situations. A network meta-analysis comparing all antireflux procedures was performed to identify which has the most favourable outcomes at short-term (3\u201312 months), medium-term (1\u20135 years) and long-term (10 years and more than 10 years) follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Article databases were searched systematically for all eligible RCTs. Primary outcomes were quality-of-life measures and dysphagia. Secondary outcomes included reflux symptoms, pH studies and complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty-one RCTs were included, involving 5357 patients and 14 different treatments. Posterior partial fundoplication ranked best in terms of reflux symptoms, and caused less dysphagia than most other interventions including Nissen fundoplication. This was consistent across all time points and outcome measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Posterior partial fundoplication provides the best balance of long-term, durable reflux control with less dysphagia, compared with other treatments.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10924","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T12:07:37Z","timestamp":1531483657000},"page":"1398-1407","source":"Crossref","is-referenced-by-count":20,"title":["Network meta-analysis of surgical management of gastro-oesophageal reflux disease in adults"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-3078","authenticated-orcid":false,"given":"M A","family":"Amer","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, University of Otago, Dunedin, New Zealand"},{"name":"Department of General Surgery, Christchurch Hospital, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M D","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Otago, Dunedin, New Zealand"},{"name":"Department of General Surgery, Dunedin Hospital, Dunedin, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Otago, Dunedin, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G P","family":"Herbison","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"McCall","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Otago, Dunedin, New Zealand"},{"name":"Department of General Surgery, Dunedin Hospital, Dunedin, New Zealand"},{"name":"Department of Surgery, School of Medicine, University of Auckland, Auckland, New Zealand"},{"name":"New Zealand Liver Transplant Unit, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"2021020616580906900_bjs10924-bib-0001","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.2004.051821","article-title":"Epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"54","author":"Dent","year":"2005","journal-title":"Gut"},{"issue":"3","key":"2021020616580906900_bjs10924-bib-0002","first-page":"CD003243","article-title":"Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults","author":"Wileman","year":"2010","journal-title":"Cochrane Database Syst 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