{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:06:36Z","timestamp":1788116796143,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana Ricerca Cancro","doi-asserted-by":"publisher","award":["12182"],"award-info":[{"award-number":["12182"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana Ricerca Cancro","doi-asserted-by":"publisher","award":["17132"],"award-info":[{"award-number":["17132"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["FIMP-CUP_J33G13000210001"],"award-info":[{"award-number":["FIMP-CUP_J33G13000210001"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011264","name":"FP7 European Community Grant Cam-Pac","doi-asserted-by":"publisher","award":["602783"],"award-info":[{"award-number":["602783"]}],"id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The association between risk of pancreatic cancer and a dilated main pancreatic duct (MPD) in intraductal papillary mucinous neoplasm (IPMN) is debated. The aim of this study was to assess the role of MPD size in predicting pancreatic cancer in resected IPMNs and those kept under surveillance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients with IPMN referred to the Pancreas Institute, University of Verona Hospital Trust, from 2006 to 2016 were included. The primary endpoint was the occurrence of malignancy detected at surgery or during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The final cohort consisted of 1688 patients with a median follow-up of 60 months. Main pancreatic duct dilatation was associated with other features of malignancy in both the resected and surveillance groups. In patients who underwent resection, only a MPD of at least 10 mm was an independent predictor of malignancy. In patients kept under surveillance, MPD dilatation was not associated with malignancy. Fifteen of 71 patients (21 per cent) with malignancy in the resection cohort had a dilated MPD alone, whereas only one of 30 (3 per cent) under surveillance with MPD dilatation alone developed malignancy. Patients with a dilated MPD and other worrisome features had an increased 5-year cumulative incidence of malignancy compared with those with a non-dilated duct (11 versus 1\u00b72 per cent; P &amp;lt; 0\u00b7001); however, the risk of malignancy was not significantly increased in patients with a dilated MPD alone (4 versus 1\u00b72 per cent; P =\u00a00\u00b7448).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients under surveillance, a dilated MPD alone was not associated with an increased incidence of malignancy in IPMN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.10948","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T09:54:04Z","timestamp":1534240444000},"page":"1825-1834","source":"Crossref","is-referenced-by-count":43,"title":["Importance of main pancreatic duct dilatation in IPMN undergoing surveillance"],"prefix":"10.1093","volume":"105","author":[{"given":"G","family":"Marchegiani","sequence":"first","affiliation":[{"name":"Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-8271","authenticated-orcid":false,"given":"S","family":"Andrianello","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Morbin","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Secchettin","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Department of Radiology, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"De Robertis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Casa di Cura Pederzoli, Peschiera del Garda, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Malleo","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bassi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Salvia","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"2021020616460540800_bjs10948-bib-0001","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.pan.2017.07.007","article-title":"Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas","volume":"17","author":"Tanaka","year":"2017","journal-title":"Pancreatology"},{"key":"2021020616460540800_bjs10948-bib-0002","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.dld.2013.01.010","article-title":"European Study Group on Cystic Tumours of the Pancreas. 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