{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:12:13Z","timestamp":1790809933938,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":927,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Consensus is lacking regarding intervention for patients with acute lower limb ischaemia (ALI). The aim was to study amputation-free survival in patients treated for ALI by either primary open or endovascular revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Swedish Vascular Registry (Swedvasc) was combined with the Population Registry and National Patient Registry to determine follow-up on mortality and amputation rates. Revascularization techniques were compared by propensity score matching 1 : 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 9736 patients who underwent open surgery and 6493 who had endovascular treatment between 1994 and 2014, 3365 remained in each group after propensity score matching. Results are from the matched cohort only. Mean age of the patients was 74\u00b77 years; 47\u00b75 per cent were women and mean follow-up was 4\u00b73 years. At 30-day follow-up, the endovascular group had better patency (83\u00b70 versus 78\u00b76 per cent; P\u00a0&amp;lt; 0\u00b7001). Amputation rates were similar at 30 days (7\u00b70 per cent in the endovascular group versus 8\u00b72 per cent in the open group; P\u00a0= 0\u00b7113) and at 1 year (13\u00b78 versus 14\u00b78 per cent; P\u00a0= 0\u00b7320). The mortality rate was lower after endovascular treatment, at 30 days (6\u00b77 versus 11\u00b71 per cent; P\u00a0&amp;lt; 0\u00b7001) and after 1 year (20\u00b72 versus 28\u00b76 per cent; P\u00a0&amp;lt; 0\u00b7001). Accordingly, endovascular treatment had better amputation-free survival at 30 days (87\u00b75 versus 82\u00b71 per cent; P\u00a0&amp;lt; 0\u00b7001) and 1 year (69\u00b79 versus 61\u00b71 per cent; P\u00a0&amp;lt; 0\u00b7001). The number needed to treat to prevent one death within the first year was 12 with an endovascular compared with an open approach. Five years after surgery, endovascular treatment still had improved survival (HR 0\u00b778, 99 per cent c.i. 0\u00b770 to 0\u00b786) but the difference between the treatment groups occurred mainly in the first year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Primary endovascular treatment for ALI appeared to reduce mortality compared with open surgery, without any difference in the risk of amputation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.10954","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T08:14:22Z","timestamp":1532506462000},"page":"1598-1606","source":"Crossref","is-referenced-by-count":71,"title":["Open or endovascular revascularization in the treatment of acute lower limb ischaemia"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-8372","authenticated-orcid":false,"given":"O","family":"Grip","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Section of Vascular Surgery, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wanhainen","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Vascular Surgery, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Micha\u00eblsson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Orthopaedics, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lindhagen","sequence":"additional","affiliation":[{"name":"UCR \u2013 Uppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bj\u00f6rck","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Vascular Surgery, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"key":"2021020616462492100_bjs10954-bib-0001","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.semvascsurg.2009.01.003","article-title":"Do randomized trials of thrombolysis versus open revascularization still apply to current management: what has changed?","volume":"22","author":"Comerota","year":"2009","journal-title":"Semin Vasc Surg"},{"issue":"1","key":"2021020616462492100_bjs10954-bib-0002","first-page":"CD000985","article-title":"Infusion techniques for peripheral arterial thrombolysis","author":"Kessel","year":"2004","journal-title":"Cochrane Database Syst 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