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The aim of this study was to evaluate the costs and cost-effectiveness of early versus delayed endovenous treatment of patients with venous leg ulcers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a within-trial cost-utility analysis with a 1-year time horizon using data from the EVRA (Early Venous Reflux Ablation) trial. The study compared early versus deferred endovenous ablation for superficial venous truncal reflux in patients with a venous leg ulcer. The outcome measure was the cost per quality-adjusted life-year (QALY) over 1 year. Sensitivity analyses were conducted with alternative methods of handling missing data, alternative preference weights for health-related quality of life, and per protocol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After early intervention, the mean(s.e.m.) cost was higher (difference in cost per patient \u00a3163(318) (\u20ac184(358))) and early intervention was associated with more QALYs at 1 year (mean(s.e.m.) difference 0\u00b7041(0\u00b7017)). The incremental cost-effectiveness ratio (ICER) was \u00a33976 (\u20ac4482) per QALY. There was an 89 per cent probability that early venous intervention is cost-effective at a threshold of \u00a320 000 (\u20ac22 546)\/QALY. Sensitivity analyses produced similar results, confirming that early treatment of superficial reflux is highly likely to be cost-effective.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Early treatment of superficial reflux is highly likely to be cost-effective in patients with venous leg ulcers over 1 year. Registration number: ISRCTN02335796 (http:\/\/www.isrctn.com).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11082","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T15:01:44Z","timestamp":1549897304000},"page":"555-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cost-effectiveness analysis of a randomized clinical trial of early <i>versus<\/i> deferred endovenous ablation of superficial venous reflux in patients with venous ulceration"],"prefix":"10.1093","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2275-0916","authenticated-orcid":false,"given":"D M","family":"Epstein","sequence":"first","affiliation":[{"name":"Department of Applied Economics, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Gohel","sequence":"additional","affiliation":[{"name":"Department of Vascular 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