{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:01:12Z","timestamp":1772488872345,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"South Region of Denmark"},{"name":"The Danish Research Council"},{"DOI":"10.13039\/100007405","name":"The Danish Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Helse Foundation"},{"DOI":"10.13039\/501100004196","name":"Odense University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Elitary Research Centre of Individualized Medicine"},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The challenge of managing age-related diseases is increasing; routine checks by the general practitioner do not reduce cardiovascular mortality. The aim here was to reduce cardiovascular mortality by advanced population-based cardiovascular screening. The present article reports the organization of the study, the acceptability of the screening offer, and the relevance of multifaceted screening for prevention and management of cardiovascular disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Danish men aged 65\u201374 years were invited randomly (1 : 2) to a cardiovascular screening examination using low-dose non-contrast CT, ankle and brachial BP measurements, and blood tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all, 16 768 of 47 322 men aged 65\u201374 years were invited and 10 471 attended (uptake 62\u00b74 per cent). Of these, 3481 (33\u00b72 per cent) had a coronary artery calcium score above 400 units. Thoracic aortic aneurysm was diagnosed in the ascending aorta (diameter 45 mm or greater) in 468 men (4\u00b75 per cent), in the arch (at least 40 mm) in 48 (0\u00b75 per cent) and in the descending aorta (35 mm or more) in 233 (2\u00b72 per cent). Abdominal aortic aneurysm (at least 30 mm) and iliac aneurysm (20 mm or greater) were diagnosed in 533 (5\u00b71 per cent) and 239 (2\u00b73 per cent) men respectively. Peripheral artery disease was diagnosed in 1147 men (11\u00b70 per cent), potentially uncontrolled hypertension (at least 160\/100 mmHg) in 835 (8\u00b70 per cent), previously unknown atrial fibrillation confirmed by ECG in 50 (0\u00b75 per cent), previously unknown diabetes mellitus in 180 (1\u00b77 per cent) and isolated severe hyperlipidaemia in 48 men (0\u00b75 per cent).<\/jats:p>\n                  <jats:p>In all, 4387 men (41\u00b79 per cent), excluding those with potentially uncontrolled hypertension, were referred for additional cardiovascular prevention. Of these, 3712 (35\u00b75 per cent of all screened men, but 84\u00b76 per cent of those referred) consented and were started on medication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Multifaceted cardiovascular screening is feasible and may optimize cardiovascular disease prevention in men aged 65\u201374 years. Uptake is lower than in aortic aneurysm screening.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11135","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T06:34:54Z","timestamp":1553754894000},"page":"862-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Baseline findings of the population-based, randomized, multifaceted Danish cardiovascular screening trial (DANCAVAS) of men aged 65\u201374 years"],"prefix":"10.1093","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-4488","authenticated-orcid":false,"given":"J S","family":"Lindholt","sequence":"first","affiliation":[{"name":"Elitary Research Centre of Individualized Medicine in Arterial Disease (CIMA), Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L M","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Elitary Research Centre of Individualized Medicine in Arterial Disease (CIMA), Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-8550","authenticated-orcid":false,"given":"R","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"Department of Public Health and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Lambrechtsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Svendborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F H","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lillebaelt Hospital, Vejle, 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