{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:33:05Z","timestamp":1791441185012,"version":"4.3.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Carotid stenosis is a common cause of ischaemic stroke and transient ischaemic attack (TIA). Despite rising recognition and centralization of stroke services there has been a decline in interventions for carotid stenosis in recent years. The aim of this study was to determine the current prevalence and management of carotid stenosis in the UK.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a 1-year prospective observational study of consecutive patients presenting with ischaemic stroke, TIA or ischaemic retinal artery occlusion to a central London hyperacute stroke unit. Patients with significant carotid stenosis, defined as atherosclerotic narrowing of 50 per cent or greater, underwent multidisciplinary team (MDT) discussion to determine the cause of stroke\/TIA and classify carotid stenosis as symptomatic or incidental.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 2707 patients were seen; half had an ischaemic event and the majority had carotid imaging (1252 of 1444). Carotid stenosis of at least 50 per cent was seen in 238 (prevalence 19\u00b70 (95 per cent c.i. 16\u00b76 to 21\u00b74) per cent). Patients with significant carotid stenosis were more likely to have hypertension, hypercholesterolaemia, diabetes and ischaemic heart disease. Carotid stenosis was deemed symptomatic in 99 patients (7\u00b79 (6\u00b73 to 9\u00b75) per cent); of these, 17 had carotid occlusion, 17 were unfit for surgery and 58 patients were referred for carotid intervention. Among 139 patients with asymptomatic stenosis, 75 had carotid stenosis ipsilateral to the stroke but, after MDT discussion, the cause was deemed to be atrial fibrillation (32), small-vessel disease (15), another determined cause (5), or not determined owing to atypical imaging or clinical presentation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Carotid stenosis is common, affecting one in five patients presenting with stroke or TIA. Careful MDT discussion may avoid unnecessary intervention and should be the standard of care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11136","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T16:03:24Z","timestamp":1554221004000},"page":"872-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Contemporary prevalence of carotid stenosis in patients presenting with ischaemic stroke"],"prefix":"10.1093","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-1723","authenticated-orcid":false,"given":"S F","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Surgery and Interventional Science, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"Brown","sequence":"additional","affiliation":[{"name":"Stroke Research Centre, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Simister","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Richards","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"2021011409344511400_bjs11136-bib-0001","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.STR.19.5.547","article-title":"The Stroke Data Bank: design, methods, and baseline characteristics","volume":"19","author":"Foulkes","year":"1988","journal-title":"Stroke"},{"key":"2021011409344511400_bjs11136-bib-0002","volume-title":"Stroke and Transient Ischaemic Attack in Over 16s: Diagnosis and Initial Management","author":"National Institute for Health and Care Excellence (NICE)","year":"2008"},{"key":"2021011409344511400_bjs11136-bib-0003","doi-asserted-by":"crossref","first-page":"g4757","DOI":"10.1136\/bmj.g4757","article-title":"Impact of centralising acute stroke services in English metropolitan areas on mortality and length of hospital stay: difference-in-differences analysis","volume":"349","author":"Morris","year":"2014","journal-title":"BMJ"},{"key":"2021011409344511400_bjs11136-bib-0004","author":"Royal College of Physicians Sentinel Stroke National Audit Programme (SSNAP)","year":"2017","journal-title":"Annual Results Portfolio April 2016 \u2013 March 2017"},{"key":"2021011409344511400_bjs11136-bib-0005","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/ageing\/aft075","article-title":"Changes in antiplatelet use prior to incident ischaemic stroke over 7 years in a UK centre and the association with stroke subtype","volume":"42","author":"White","year":"2013","journal-title":"Age Ageing"},{"key":"2021011409344511400_bjs11136-bib-0006","author":"Royal College of Surgeons of England, Vascular Society of Great Britain and Ireland (VSGBI)","year":"2018","journal-title":"National Vascular Registry, 2017 Annual Report, Version 2"},{"key":"2021011409344511400_bjs11136-bib-0007","volume-title":"National Vascular Registry, UK Carotid Endarterectomy Audit. 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