{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:46:15Z","timestamp":1793317575903,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015250","name":"National Institute for Health Research Academic Clinical Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Gallstones account for 30\u201350 per cent of all presentations of acute pancreatitis. While the management of acute pancreatitis is usually supportive, definitive treatment of gallstone pancreatitis is cholecystectomy. Guidelines from the British Society of Gastroenterology suggest definitive treatment on index admission or within 2 weeks of discharge, whereas joint recommendations from the International Association of Pancreatology and the American Pancreatic Association recommend definitive treatment on index admission. Evidence suggests that uptake of these guidelines is low.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Embase, MEDLINE and Cochrane databases were searched for RCTs investigating early versus delayed cholecystectomy in patients with a confirmed diagnosis of mild gallstone pancreatitis. The pooled synthesis was undertaken using a random-effects meta-analysis of the primary outcome of recurrent biliary complications causing hospital readmission. Secondary outcomes included intraoperative and postoperative complications, and total length of hospital stay (LOS). All analyses were performed using RevMan5 software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five RCTs were identified, which included 629 patients (318 in the early cholecystectomy (EC) group and 311 in the delayed cholecystectomy (DC) group). Recurrent biliary events that required readmission were reduced in patients undergoing EC compared with the number in patients having DC (odds ratio (OR) 0\u00b717, 95 per cent c.i. 0\u00b709 to 0\u00b733). There was no difference in the rate of intraoperative (OR 0\u00b758, 0\u00b717 to 1\u00b792) or postoperative (OR 0\u00b778, 0\u00b738 to 1\u00b762) complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>EC following mild gallstone pancreatitis does not increase the risk of intraoperative or postoperative complications, but reduces the readmission rate for recurrent biliary complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11221","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T11:44:46Z","timestamp":1562154286000},"page":"1442-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Meta-analysis of randomized clinical trials of early <i>versus<\/i> delayed cholecystectomy for mild gallstone pancreatitis"],"prefix":"10.1093","volume":"106","author":[{"given":"N","family":"Moody","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Queen's Medical Centre , Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-6197","authenticated-orcid":false,"given":"A","family":"Adiamah","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Queen's Medical Centre , Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8849-2446","authenticated-orcid":false,"given":"F","family":"Yanni","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Queen's Medical Centre , Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Queen's Medical Centre , Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"2022100812450274600_bjs11221-bib-0001","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bpg.2007.10.007","article-title":"Epidemiology, aetiology and outcome of acute and chronic pancreatitis: an update","volume":"22","author":"Spanier","year":"2008","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2022100812450274600_bjs11221-bib-0002","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.clnu.2017.09.028","article-title":"A systematic review of the epidemiology, pathophysiology and current management of hyperlipidaemic pancreatitis","volume":"37","author":"Adiamah","year":"2018","journal-title":"Clin Nutr"},{"key":"2022100812450274600_bjs11221-bib-0003","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/bjs.1800810632","article-title":"Multicentre audit of death from acute pancreatitis","volume":"81","author":"Mann","year":"1994","journal-title":"Br J Surg"},{"key":"2022100812450274600_bjs11221-bib-0004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/gut.37.1.121","article-title":"Factors influencing morbidity and mortality in acute pancreatitis; 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