{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:50:14Z","timestamp":1773269414157,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Italian Ministry of Health","award":["Progetti ordinari di Ricerca Finalizzata, RF- 2011-02349645"],"award-info":[{"award-number":["Progetti ordinari di Ricerca Finalizzata, RF- 2011-02349645"]}]},{"name":"Italian Ministry of Health","award":["Progetti ordinari di Ricerca Finalizzata, RF- 2011-02349645"],"award-info":[{"award-number":["Progetti ordinari di Ricerca Finalizzata, RF- 2011-02349645"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Colonic J pouch reconstruction has been found to be associated with a lower incidence of anastomotic leakage than straight anastomosis. However, studies on this topic are underpowered and retrospective. This randomized trial evaluated whether the incidence of anastomotic leakage was reduced after colonic J pouch reconstruction compared with straight colorectal anastomosis following anterior resection for rectal cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This multicentre RCT included patients with rectal carcinoma who underwent low anterior resection followed by colorectal anastomosis. Patients were assigned randomly to receive a colonic J pouch or straight colorectal anastomosis. The main outcome measure was the occurrence of major anastomotic leakage. The incidence of global (major plus minor) anastomotic leakage and general complications were secondary outcomes. Risk factors for anastomotic leakage were identified by regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 457 patients enrolled, 379 were evaluable (colonic J pouch arm 190, straight colorectal arm 189). The incidence of major and global anastomotic leakage, and general complications was 14\u00b72, 19\u00b75 and 34\u00b72 per cent respectively in the colonic J pouch group, and 12\u00b72, 19\u00b70 and 27\u00b70 per cent in the straight colorectal anastomosis group. No statistically significant differences were observed between the two arms. In multivariable logistic regression analysis, male sex (odds ratio 1\u00b779, 95 per cent c.i. 1\u00b702 to 3\u00b715; P = 0\u00b7042) and high ASA fitness grade (odds ratio 2\u00b706, 1\u00b715 to 3\u00b771; P = 0\u00b7015) were independently associated with the occurrence of anastomotic leakage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Colonic J pouch reconstruction does not reduce the incidence of anastomotic leakage and postoperative complications compared with conventional straight colorectal anastomosis. Registration number NCT01110798 (http:\/\/www.clinicaltrials.gov).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11222","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T17:33:13Z","timestamp":1561483993000},"page":"1147-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Multicentre randomized clinical trial of colonic J pouch or straight stapled colorectal reconstruction after low anterior resection for rectal cancer"],"prefix":"10.1093","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5289-9925","authenticated-orcid":false,"given":"S","family":"Pucciarelli","sequence":"first","affiliation":[{"name":"First Surgical Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua , Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Del Bianco","sequence":"additional","affiliation":[{"name":"Clinical Trials and Biostatistics Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS , Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Pace","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgical Oncology, Istituto Nazionale Tumori \u2013 IRCCS Fondazione G. Pascale , Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Abdominal Oncology, Istituto Nazionale Tumori \u2013 IRCCS Fondazione G. Pascale , Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Restivo","sequence":"additional","affiliation":[{"name":"Colorectal Surgery, Azienda Ospedaliero\u2013Universitaria di Cagliari, Department of Surgical Science, University of Cagliari , Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Maretto","sequence":"additional","affiliation":[{"name":"First Surgical Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua , Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Selvaggi","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, University of Campania \u2018Luigi Vanvitelli\u2019 , Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Zorcolo","sequence":"additional","affiliation":[{"name":"Colorectal Surgery, Azienda Ospedaliero\u2013Universitaria di Cagliari, Department of Surgical Science, University of Cagliari , Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"De Franciscis","sequence":"additional","affiliation":[{"name":"Department of Abdominal Oncology, Istituto Nazionale Tumori \u2013 IRCCS Fondazione G. 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